- Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance. Gangjee, A., Zhao, Y., Lin, L., Raghavan, S., Roberts, E.G., Risinger, A.L., Hamel, E., Mooberry, S.L. J. Med. Chem. (2010)