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Aleem Gangjee

Division of Medicinal Chemistry

Graduate School of Pharmaceutical Sciences

Duquesne University

Pittsburgh

USA

[email]@duq.edu

Name/email consistency: high

 
 
 
 
 
 
 

Affiliation

  • Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, USA. 2000 - 2012

References

  1. Novel Water-Soluble Substituted Pyrrolo[3,2-d]pyrimidines: Design, Synthesis, and Biological Evaluation as Antitubulin Antitumor Agents. Gangjee, A., Pavana, R.K., Li, W., Hamel, E., Westbrook, C., Mooberry, S.L. Pharm. Res. (2012) [Pubmed]
  2. 2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors. Gangjee, A., Jain, H.D., Phan, J., Guo, X., Queener, S.F., Kisliuk, R.L. Bioorg. Med. Chem. (2010) [Pubmed]
  3. Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents. Gangjee, A., Kurup, S., Ihnat, M.A., Thorpe, J.E., Shenoy, S.S. Bioorg. Med. Chem. (2010) [Pubmed]
  4. The contribution of a 2-amino group on receptor tyrosine kinase inhibition and antiangiogenic activity in 4-anilinosubstituted pyrrolo[2,3-d]pyrimidines. Gangjee, A., Namjoshi, O.A., Ihnat, M.A., Buchanan, A. Bioorg. Med. Chem. Lett. (2010) [Pubmed]
  5. Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance. Gangjee, A., Zhao, Y., Lin, L., Raghavan, S., Roberts, E.G., Risinger, A.L., Hamel, E., Mooberry, S.L. J. Med. Chem. (2010) [Pubmed]
  6. Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents. Gangjee, A., Zhao, Y., Raghavan, S., Ihnat, M.A., Disch, B.C. Bioorg. Med. Chem. (2010) [Pubmed]
  7. Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. Gangjee, A., Zaware, N., Raghavan, S., Ihnat, M., Shenoy, S., Kisliuk, R.L. J. Med. Chem. (2010) [Pubmed]
  8. CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified cross-validated r(2)-guided region selection (q(2)-GRS) routine and its initial application. Gangjee, A., Lin, X., Biondo, L.R., Queener, S.F. Bioorg. Med. Chem. (2010) [Pubmed]
  9. Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. Gangjee, A., Li, W., Kisliuk, R.L., Cody, V., Pace, J., Piraino, J., Makin, J. J. Med. Chem. (2009) [Pubmed]
  10. Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors. Gangjee, A., Li, W., Lin, L., Zeng, Y., Ihnat, M., Warnke, L.A., Green, D.W., Cody, V., Pace, J., Queener, S.F. Bioorg. Med. Chem. (2009) [Pubmed]
  11. Potent dual thymidylate synthase and dihydrofolate reductase inhibitors: classical and nonclassical 2-amino-4-oxo-5-arylthio-substituted-6-methylthieno[2,3-d]pyrimidine antifolates. Gangjee, A., Qiu, Y., Li, W., Kisliuk, R.L. J. Med. Chem. (2008) [Pubmed]
  12. N9-substituted 2,4-diaminoquinazolines: synthesis and biological evaluation of lipophilic inhibitors of pneumocystis carinii and toxoplasma gondii dihydrofolate reductase. Gangjee, A., Adair, O.O., Pagley, M., Queener, S.F. J. Med. Chem. (2008) [Pubmed]
  13. The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents. Gangjee, A., Jain, H.D., Queener, S.F., Kisliuk, R.L. J. Med. Chem. (2008) [Pubmed]
  14. Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents. Gangjee, A., Namjoshi, O.A., Yu, J., Ihnat, M.A., Thorpe, J.E., Warnke, L.A. Bioorg. Med. Chem. (2008) [Pubmed]
  15. Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: Part II. Gangjee, A., Jain, H.D., Kurup, S. Anticancer. Agents. Med. Chem (2008) [Pubmed]
  16. Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. Gangjee, A., Li, W., Yang, J., Kisliuk, R.L. J. Med. Chem. (2008) [Pubmed]
  17. Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: part I. Gangjee, A., Jain, H.D., Kurup, S. Anticancer. Agents. Med. Chem (2007) [Pubmed]
  18. Discovery of novel antitumor antimitotic agents that also reverse tumor resistance. Gangjee, A., Yu, J., Copper, J.E., Smith, C.D. J. Med. Chem. (2007) [Pubmed]
  19. Dihydrofolate reductase as a target for chemotherapy in parasites. Gangjee, A., Kurup, S., Namjoshi, O. Curr. Pharm. Des. (2007) [Pubmed]
  20. Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as antifolates. Gangjee, A., Zeng, Y., Talreja, T., McGuire, J.J., Kisliuk, R.L., Queener, S.F. J. Med. Chem. (2007) [Pubmed]
  21. Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1). Gangjee, A., Jain, H.D., Phan, J., Lin, X., Song, X., McGuire, J.J., Kisliuk, R.L. J. Med. Chem. (2006) [Pubmed]
  22. Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as antifolates. Gangjee, A., Yang, J., McGuire, J.J., Kisliuk, R.L. Bioorg. Med. Chem. (2006) [Pubmed]
  23. Novel non-classical C9-methyl-5-substituted-2,4-diaminopyrrolo[2,3-d]pyrimidines as potential inhibitors of dihydrofolate reductase and as anti-opportunistic agents. Gangjee, A., Yang, J., Queener, S.F. Bioorg. Med. Chem. (2006) [Pubmed]
  24. CoMFA and CoMSIA analyses of Pneumocystis carinii dihydrofolate reductase, Toxoplasma gondii dihydrofolate reductase, and rat liver dihydrofolate reductase. Gangjee, A., Lin, X. J. Med. Chem. (2005) [Pubmed]
  25. Novel 2-amino-4-oxo-5-arylthio-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase. Gangjee, A., Jain, H.D., Kisliuk, R.L. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
  26. Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates. Gangjee, A., Zeng, Y., McGuire, J.J., Kisliuk, R.L. J. Med. Chem. (2005) [Pubmed]
  27. Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents. Gangjee, A., Lin, X., Kisliuk, R.L., McGuire, J.J. J. Med. Chem. (2005) [Pubmed]
  28. Design, synthesis, and biological evaluation of 2,4-diamino-5-methyl-6-substituted-pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors. Gangjee, A., Lin, X., Queener, S.F. J. Med. Chem. (2004) [Pubmed]
  29. Antifolates -- past, present and future. Gangjee, A., Jain, H.D. Curr. Med. Chem. Anticancer. Agents (2004) [Pubmed]
  30. Benzoyl ring halogenated classical 2-amino-6-methyl-3,4-dihydro-4-oxo-5-substituted thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine antifolates as inhibitors of thymidylate synthase and as antitumor agents. Gangjee, A., Jain, H.D., McGuire, J.J., Kisliuk, R.L. J. Med. Chem. (2004) [Pubmed]
  31. Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates. Gangjee, A., Zeng, Y., McGuire, J.J., Mehraein, F., Kisliuk, R.L. J. Med. Chem. (2004) [Pubmed]
  32. Design, synthesis, and biological activities of classical N-[4-[2-(2-amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and its 6-methyl derivative as potential dual inhibitors of thymidylate synthase and dihydrofolate reductase and as potential antitumor agents. Gangjee, A., Yu, J., Kisliuk, R.L., Haile, W.H., Sobrero, G., McGuire, J.J. J. Med. Chem. (2003) [Pubmed]
  33. Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents. Gangjee, A., Adair, O.O., Queener, S.F. J. Med. Chem. (2003) [Pubmed]
  34. Antiangiogenic and antitumor agents. Design, synthesis, and evaluation of novel 2-amino-4-(3-bromoanilino)-6-benzylsubstituted pyrrolo[2,3-d]pyrimidines as inhibitors of receptor tyrosine kinases. Gangjee, A., Yang, J., Ihnat, M.A., Kamat, S. Bioorg. Med. Chem. (2003) [Pubmed]
  35. Synthesis of N-[4-[1-ethyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid as an antifolate. Gangjee, A., Zeng, Y., McGuire, J.J., Kisliuk, R.L. J. Med. Chem. (2002) [Pubmed]
  36. Synthesis of classical and nonclassical, partially restricted, linear, tricyclic 5-deaza antifolates. Gangjee, A., Zeng, Y., McGuire, J.J., Kisliuk, R.L. J. Med. Chem. (2002) [Pubmed]
  37. Recent advances in the chemistry and biology of folypoly-gamma-glutamate synthetase substrates and inhibitors. Gangjee, A., Dubash, N.P., Zeng, Y., McGuire, J.J. Curr. Med. Chem. Anticancer. Agents (2002) [Pubmed]
  38. Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines. Gangjee, A., Vidwans, A., Elzein, E., McGuire, J.J., Queener, S.F., Kisliuk, R.L. J. Med. Chem. (2001) [Pubmed]
  39. Synthesis of 2,4-diamino-6-(thioarylmethyl)pyrido[2,3-d]pyrimidines as dihydrofolate reductase inhibitors. Gangjee, A., Adair, O., Queener, S.F. Bioorg. Med. Chem. (2001) [Pubmed]
  40. Effect of C9-methyl substitution and C8-C9 conformational restriction on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines. Gangjee, A., Zeng, Y., McGuire, J.J., Kisliuk, R.L. J. Med. Chem. (2000) [Pubmed]
  41. Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent. Gangjee, A., Yu, J., McGuire, J.J., Cody, V., Galitsky, N., Kisliuk, R.L., Queener, S.F. J. Med. Chem. (2000) [Pubmed]
 
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