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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Lymphocyte subset populations in bronchiolitis obliterans after heart-lung transplantation.

The long-term success of heart-lung transplantation is limited by the development of bronchiolitis obliterans, possibly as a form of chronic lung allograft rejection. In the present study, we have characterized by immunohistochemical staining the lymphocytes infiltrating the lesions of bronchiolitis obliterans in one patient following heart-lung transplantation. The finding that the preponderant cells expressed the CD8 (putative cytotoxic/suppressor) marker lends support to the notion that chronic rejection is at least one mechanism for the development of bronchiolotis obliterans following heart-lung transplantation.[1]


  1. Lymphocyte subset populations in bronchiolitis obliterans after heart-lung transplantation. Holland, V.A., Cagle, P.T., Windsor, N.T., Noon, G.P., Greenberg, S.D., Lawrence, E.C. Transplantation (1990) [Pubmed]
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