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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Bronchiolitis

 
 
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Disease relevance of Bronchiolitis

 

High impact information on Bronchiolitis

 

Chemical compound and disease context of Bronchiolitis

 

Biological context of Bronchiolitis

 

Anatomical context of Bronchiolitis

  • These in vitro findings showing that dex failed to consistently inhibit all the RSV-induced release of neutrophil inflammatory mediators may explain the variable efficacy of corticosteroids in the treatment of RSV bronchiolitis [20].
  • The percentage of BAL eosinophils correlated significantly with levels of BAL IL-5 in both the asthma group (r = 0.80, P =.000) and the bronchiolitis group (r = 0.82, P =.000) [21].
  • These results are in agreement with the reduced cyclic adenosine monophosphate response to different agonists demonstrated in leukocytes from patients with asthma, and suggest that this refractoriness could be one of the precipitating events in the development of asthma observed in a large proportion of infants who have had bronchiolitis [22].
  • The IL-4/interferon-gamma ratio for infants with acute bronchiolitis was elevated in nasal lavage fluid on both Days 1-2 (p = 0.014) and Days 5-7 (p = 0.001) of the illness compared with infants with upper respiratory tract infection alone [23].
  • Therefore, the inflammatory process in RSV-induced bronchiolitis appears to be triggered by the infection of epithelial cells and further amplified via mechanisms driven by IFN-gamma and by the secretion of eosinophil chemokines [24].
 

Gene context of Bronchiolitis

  • Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome [25].
  • Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome [26].
  • Smad3 deficiency ameliorates experimental obliterative bronchiolitis in a heterotopic tracheal transplantation model [27].
  • Additionally, MIP-1-alpha, IL-8, and RANTES concentrations were measured from lower respiratory secretions obtained from 10 intubated infants (0-24 mo) with RSV bronchiolitis, and from 10 control subjects [28].
  • IL-10 responses during the acute phase of RSV bronchiolitis were comparable to those in healthy control subjects [15].
 

Analytical, diagnostic and therapeutic context of Bronchiolitis

References

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  2. 2'-5' Oligoadenylate synthetase plays a critical role in interferon-gamma inhibition of respiratory syncytial virus infection of human epithelial cells. Behera, A.K., Kumar, M., Lockey, R.F., Mohapatra, S.S. J. Biol. Chem. (2002) [Pubmed]
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  17. Genetic variation at the IL10 gene locus is associated with severity of respiratory syncytial virus bronchiolitis. Wilson, J., Rowlands, K., Rockett, K., Moore, C., Lockhart, E., Sharland, M., Kwiatkowski, D., Hull, J. J. Infect. Dis. (2005) [Pubmed]
  18. Haplotype mapping of the bronchiolitis susceptibility locus near IL8. Hull, J., Rowlands, K., Lockhart, E., Sharland, M., Moore, C., Hanchard, N., Kwiatkowski, D.P. Hum. Genet. (2004) [Pubmed]
  19. Bronchial asthma and hyperreactivity after early childhood bronchiolitis or pneumonia. An 8-year follow-up study. Korppi, M., Kuikka, L., Reijonen, T., Remes, K., Juntunen-Backman, K., Launiala, K. Archives of pediatrics & adolescent medicine. (1994) [Pubmed]
  20. Respiratory syncytial virus stimulates neutrophil degranulation and chemokine release. Jaovisidha, P., Peeples, M.E., Brees, A.A., Carpenter, L.R., Moy, J.N. J. Immunol. (1999) [Pubmed]
  21. Bronchoalveolar lavage cytokine profiles in acute asthma and acute bronchiolitis. Kim, C.K., Kim, S.W., Park, C.S., Kim, B.I., Kang, H., Koh, Y.Y. J. Allergy Clin. Immunol. (2003) [Pubmed]
  22. Nonspecific refractoriness to adenylyl cyclase stimulation in alveolar macrophages from infants with recurrent bronchiolitis. Galoppin, L., de Blic, J., Azevedo, I., Scheinmann, P., Vargaftig, B.B., Bachelet, M. J. Allergy Clin. Immunol. (1994) [Pubmed]
  23. Type 1 and type 2 cytokine imbalance in acute respiratory syncytial virus bronchiolitis. Legg, J.P., Hussain, I.R., Warner, J.A., Johnston, S.L., Warner, J.O. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  24. Cell-specific expression of RANTES, MCP-1, and MIP-1alpha by lower airway epithelial cells and eosinophils infected with respiratory syncytial virus. Olszewska-Pazdrak, B., Casola, A., Saito, T., Alam, R., Crowe, S.E., Mei, F., Ogra, P.L., Garofalo, R.P. J. Virol. (1998) [Pubmed]
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  26. Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome. Belperio, J.A., Keane, M.P., Burdick, M.D., Lynch, J.P., Xue, Y.Y., Li, K., Ross, D.J., Strieter, R.M. J. Immunol. (2002) [Pubmed]
  27. Smad3 deficiency ameliorates experimental obliterative bronchiolitis in a heterotopic tracheal transplantation model. Ramirez, A.M., Takagawa, S., Sekosan, M., Jaffe, H.A., Varga, J., Roman, J. Am. J. Pathol. (2004) [Pubmed]
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