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Cuenca-Estrella, M. et al.

M. Cuenca-Estrella, A. Gomez-Lopez, I. Cuesta, O. Zaragoza, E. Mellado, J.L. Rodriguez-Tudela,

Frequency of voriconazole resistance in vitro among Spanish clinical isolates of Candida spp. According to breakpoints established by the Antifungal Subcommittee of the European Committee on Antimicrobial Susceptibility Testing.

A total of 4,226 Spanish clinical isolates of Candida spp. were analyzed to assess resistance to voriconazole according to breakpoints established by the European Committee for Antimicrobial Susceptibility Testing (where susceptibility [S] to voriconazole corresponds to a MIC of ≤ 0.12 mg/liter). Resistance was uncommon among Candida albicans (5%), C. parapsilosis (1.2%), and C. tropicalis (11%) isolates. Voriconazole MICs of >0.12 mg/liter were more frequent among Candida glabrata and C. krusei isolates. A significant percentage of voriconazole-resistant strains came from oropharyngeal infections and exhibited high MICs of other azoles.[1]

References

Frequency of voriconazole resistance in vitro among Spanish clinical isolates of Candida spp. According to breakpoints established by the Antifungal Subcommittee of the European Committee on Antimicrobial Susceptibility Testing. Cuenca-Estrella, M., Gomez-Lopez, A., Cuesta, I., Zaragoza, O., Mellado, E., Rodriguez-Tudela, J.L. Antimicrob. Agents Chemother. (2011) [Pubmed]

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