Disease relevance of Candida glabrata

• Treatment of Torulopsis glabrata peritonitis with intraperitoneal amphotericin B [1].
• Renal abscess and fungemia due to Torulopsis glabrata: successful treatment with drainage and fluconazole [2].
• Fungal retinitis: a case of Torulopsis glabrata infection treated with miconazole [3].
• Hepatic abscesses and fungemia from Torulopsis glabrata. Successful treatment with percutaneous drainage and amphotericin B [4].
• Vulvovaginitis caused by Candida (Torulopsis) glabrata is often refractory to intravaginal imidazole therapy [5].

High impact information on Candida glabrata

• Unique transcripts for cytochrome b, ATPase subunits 6 and 9, cytochrome oxidase subunits 2 and 3 and S and L rRNA have been mapped by the S1 protection technique to the circular 19-kbp mitochondrial DNA (mtDNA) of the yeast Torulopsis glabrata [6].
• Fluconazole prevents colonization and infection with Candida species other than C. krusei and Torulopsis glabrata before marrow engraftment [7].
• var1 Gene on the mitochondrial genome of Torulopsis glabrata [8].
• The sterol analogues were tested for in vitro antifungal activity against C. albicans, Candida tropicalis, and Torulopsis glabrata [9].
• When all fungi were considered, the difference in colonization was less but was still significant (117 [43%] of 274 vs. 173 [54%] of 322; P = .01), primarily due to increased colonization of the rectum with Torulopsis glabrata among ketoconazole recipients (P less than .001) [10].

Chemical compound and disease context of Candida glabrata

• 1-[(4-Biphenylyl)-phenylmethyl]-1H-imidazole (bifonazole, Bay h 4502, Mycospor) showed in vitro significant inhibitory activity against Torulopsis glabrata, Candida albicans, Pityrosporum ovale, Corynebacterium acnes and Staphylococcus epidermidis [11].

Biological context of Candida glabrata

• Abstract Aims: This study aimed at further increasing the pyruvate productivity of a multi-vitamin auxotrophic yeast Torulopsis glabrata by redirecting ATP production from oxidative phosphorylation to substrate-level phosphorylation [12].

Anatomical context of Candida glabrata

• Intra-species fusion products of Saccharomyces cerevisiae, Saccharomyces unisporus and Torulopsis glabrata have been isolated following polyethylene glycol-induced fusion of protoplasts and selection for prototrophic colonies [13].
• The effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) on the interaction between the fungus Torulopsis glabrata and human neutrophils was examined [14].
• Control of the yeast Torulopsis glabrata in the stomachs of glucose fed lambs by oral dosing with nystatin and amphotericin "B" [15].

Associations of Candida glabrata with chemical compounds

• Treatment of disseminated Torulopsis glabrata infection with DO870 and amphotericin B [16].
• Susceptibility to 4 micrograms of miconazole and miconazole nitrate per ml occurred in 73 and 87% of Torulopsis glabrata strains, respectively, and none was susceptible to ketoconazole [17].
• In vitro activities of miconazole, miconazole nitrate, and ketoconazole alone and combined with rifampin against Candida spp. and Torulopsis glabrata recovered from cancer patients [17].
• Chlorpromazine also inhibited C. krusei, C. parapsilosis, C. tropicalis, and Torulopsis glabrata [18].
• Only low or inconsistent estrogen or androgen binding was found in Blastomyces dermatitidis and Torulopsis glabrata [19].

Gene context of Candida glabrata

• Candida (Torulopsis) glabrata is frequently isolated in cases of fungal infection and commonly shows acquired or innate fluconazole resistance [20].
• Discriminative power of fatty acid methyl ester (FAME) analysis using the microbial identification system (MIS) for Candida (Torulopsis) glabrata and Saccharomyces cerevisiae [20].

Analytical, diagnostic and therapeutic context of Candida glabrata

• 1-[(4-Biphenylyl)-phenylmethyl]-1H-imidazole (bifonazole, Bay h 4502, Mycospor) induced profound ultrastructural alterations in Candida albicans and Torulopsis glabrata as observed by freeze fracture electron microscopy [21].

References