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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Modak, S. et al.

Shakeel Modak, Irene Y. Cheung, Brian H. Kushner, Kim Kramer, Lilian Reich, Nai-Kong V. Cheung,

Plerixafor plus granulocyte-colony stimulating factor for autologous hematopoietic stem cell mobilization in patients with metastatic neuroblastoma.

Current therapies for high-risk neuroblastoma (NB) necessitate the availability of several aliquots of autologous peripheral blood stem cells to reverse-associated myelosuppression. Priming with the CXCR4 inhibitor plerixafor plus G-CSF was associated with successful stem cell harvest in 5/7 heavily prior-treated patients with stage 4 NB who had previously failed G-CSF priming. Minimal residual disease was not detected in harvested cells from any patient despite the presence of disease in bone/bone marrow in 6/7. Hematopoietic reconstitution was achieved in all three patients receiving plerixafor-primed stem cells after myeloablative therapy. Plerixafor is an effective and safe agent for stem cell collection in patients with NB. Pediatr Blood Cancer 2012; 58: 469-471. © 2011 Wiley Periodicals, Inc.[1]

References

Plerixafor plus granulocyte-colony stimulating factor for autologous hematopoietic stem cell mobilization in patients with metastatic neuroblastoma. Modak, S., Cheung, I.Y., Kushner, B.H., Kramer, K., Reich, L., Cheung, N.K. Pediatr. Blood. Cancer (2012) [Pubmed]

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