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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Contact allergy to Australian blackwood (Acacia melanoxylon R.Br.): isolation and identification of new hydroxyflavan sensitizers.

Australian blackwood is known to be an important cause of allergic contact dermatitis in Australia. Previous investigations have shown that 2,6-dimethoxy-1,4-benzoquinone and acamelin are 2 of the responsible, but weak, sensitizers. When these 2 quinones are lacking, which is occasionally found, the wood still possesses allergenic properties. The present re-examination led to the isolation and identification of 4 hydroxyflavans, of which 3 proved to be allergens. Melacacidin, known to be the main constituent of these flavan derivatives in the heartwood, was isolated and its sensitizing capacity in guinea pigs determined. It showed a moderate sensitizing power. Melacacidin occurs abundantly in 125 Australian and 3 African Acacia species.[1]

References

  1. Contact allergy to Australian blackwood (Acacia melanoxylon R.Br.): isolation and identification of new hydroxyflavan sensitizers. Hausen, B.M., Bruhn, G., Tilsley, D.A. Contact Derm. (1990) [Pubmed]
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