Disease relevance of Dermatitis, Allergic Contact

• OBJECTIVE: To assess the effect of white petrolatum vs bacitracin ointment on wound infection incidence, allergic contact dermatitis incidence, and healing characteristics [1].
• Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen [2].
• In contrast to normal skin and psoriasis, a significant enhancement of perforin and granzyme B gene expression and immunoreactivity was observed in the mononuclear cell infiltrate of allergic contact dermatitis [3].
• This implicates TNF alpha in the pathogenesis of psoriasis, fixed drug eruption, atopic and allergic contact dermatitis [4].
• Glutathione metabolism in mice is enhanced more with hapten-induced allergic contact dermatitis than with irritant contact dermatitis [5].

High impact information on Dermatitis, Allergic Contact

• Letter: Allergic contact dermatitis due to idoxuridine [6].
• Chemical and dermatotoxicological investigations of the natural and processed resin of the Mexican rubber plant, guayule (Parthenium argentatum), has established the presence of a sesquiterpene cinnamic acid ester (guayulin A) that is a potent elicitor of allergic contact dermatitis in experimental animals [7].
• Allergic contact dermatitis secondary to topical nitroglycerin [8].
• An urushiol-specific, interleukin 2 (IL-2)-dependent T cell clone (RLB9-7) was generated from the peripheral blood of a patient with a history of allergic contact dermatitis to T. radicans [9].
• We have found a high incidence (4.8%) of allergy to hydrocortisone in patients with suspected allergic contact dermatitis [10].

Chemical compound and disease context of Dermatitis, Allergic Contact

• No patient in the group using white petrolatum developed allergic contact dermatitis vs 4 patients (0.9%) in the group using bacitracin (P=.12) [1].
• Allergic contact dermatitis with transdermal clonidine [11].
• This biphasic pattern of ear swelling seen in IgE-sensitized mice was temporally indistinguishable from that observed in mice conventionally sensitized for allergic contact dermatitis reactions by epicutaneous application of DNFB 5 days before DNFB ear challenge [12].
• Neutral endopeptidase terminates substance P-induced inflammation in allergic contact dermatitis [13].
• EMLA cream-induced allergic contact dermatitis: a role for prilocaine as an immunogen [14].

Biological context of Dermatitis, Allergic Contact

• Allergic contact dermatitis in response to budesonide reactivated by inhalation of the allergen [15].
• OBJECTIVES: The objectives of this study were to assess the anti-inflammatory effects of nanocrystalline silver using a murine model of allergic contact dermatitis, compare the effects with those of tacrolimus and a high potency steroid, and to relate the effects to modulation of pro-inflammatory cytokines and apoptosis of inflammatory cells [16].
• Whereas the role of NO in numerous skin diseases including wound healing, burn injury, psoriasis, irritant and allergic contact dermatitis, ultraviolet (UV) light-induced sunburn erythema and the control of skin infections has been extensively documented, the intracutaneous role of peroxynitrite and PARP has not been fully explored [17].
• The kinetics of expression of the intercellular adhesion molecule-1 (ICAM-1) were studied on keratinocytes in skin biopsy specimens of sensitive persons in whom the haptens were applied in a standardized format for allergic contact dermatitis testing [18].
• Allergic contact dermatitis from benzydamine with probable cross-reaction to indomethacin [19].

Anatomical context of Dermatitis, Allergic Contact

• During inflammatory skin disorders such as psoriasis, atopic dermatitis, and allergic contact dermatitis, epidermal keratinocytes overexpress large amounts of soluble epidermal growth factor receptor ligands in response to tumor necrosis factor alpha and interferon gamma [20].
• As in classical allergic contact dermatitis, the skin inflammation in primary allergic contact dermatitis was mediated by interferon-gamma producing, CD8+ effector T cells that were induced in the draining lymph nodes at day 5 postsensitization and downregulated by CD4+ T cells [21].
• Profound alterations in the dermal microvasculature and the closely related fixed tissue mast cells were observed in allergic contact dermatitis reactions to dinitrochlorobenzene and urushiol in man [22].
• BACKGROUND: We report on two cases of allergic contact dermatitis to chloramphenicol and azidamphenicol respectively, with in vivo and in vitro lymphocyte reactivity to both compounds [23].
• Cyclophosphamide intensifies the acquisition of allergic contact dermatitis in mice rendered B-cell deficient by heterologous anti-IgM antisera [24].

Gene context of Dermatitis, Allergic Contact

• SOCS1, SOCS2, and SOCS3 proteins were undetectable in healthy skin and highly expressed in the epidermis of psoriasis and allergic contact dermatitis, but were only weakly expressed in atopic dermatitis skin [25].
• Association of allergic contact dermatitis with a promoter polymorphism in the IL16 gene [26].
• Expression of CS-1 fibronectin precedes monocyte chemoattractant protein-1 production during elicitation of allergic contact dermatitis [27].
• Secondary lymphoid tissue chemokine (CCL21) is upregulated in allergic contact dermatitis [28].
• Interleukin-4 and the interleukin-4 receptor in allergic contact dermatitis [29].

Analytical, diagnostic and therapeutic context of Dermatitis, Allergic Contact

• In this presentation we document the clinical and patch test findings of nine patients seen in the past year with allergic contact dermatitis to bacitracin ointment [30].
• OBJECTIVE: To determine whether the Contact Allergen Replacement Database would improve clinical outcomes for patients with allergic contact dermatitis associated with topical skin care products by helping patients avoid known allergens [31].
• Immunofluorescence techniques were used to find out whether immunoglobulins (Ig) and complement (C3) determinants are present on the membrane of eosinophilic granulocytes in atopic patients and in patients with an allergic contact dermatitis [32].
• The Allergen Bank was established to give dermatologists easy access to special test materials in order to make early diagnoses of special cases of allergic contact dermatitis [33].
• Occupational allergic contact dermatitis from diphenylguanidine in a gas mask [34].

References