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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Acute Severe Colitis: Infliximab and/or Cyclosporine?

Acute severe ulcerative colitis is a serious condition that requires early hospitalization, with intensive monitoring and treatment. Despite the recent progress in the medical approach of Inflammatory Bowel Diseases acute severe ulcerative colitis remains a clinical challenge, with a mortality rate of nearly 1%. As of today, I.V. corticosteroids remain the 1(st)-line therapy for this complication. For non-responders (up to one-third of patients) possible options are surgery - whose timing is a critical point in the overall management of the disease - or rescue therapy with 2(nd)- line agents such as Cyclosporine and Infliximab. Here we will review the published studies dealing with the use of these medications in acute severe ulcerative colitis.[1]

References

  1. Acute Severe Colitis: Infliximab and/or Cyclosporine? Fabro, M., Szabo, H., Terrosu, G., Avellini, C., Tabuso, M., Fiorino, G., Sorrentino, D. Curr. Drug. Targets (2011) [Pubmed]
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