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Stevenson, D.A. et al.

David A. Stevenson, David H. Viskochil, John C. Carey, Xiaoming Sheng, Mary Murray, Laurie Moyer-Mileur, Judd Shelton, William L. Roberts, Ashley M. Bunker, Heather Hanson, Stephanie Bauer, Jacques L. D'Astous,

Pediatric 25-hydroxyvitamin D concentrations in neurofibromatosis type 1.

OBJECTIVE: Low 25-hydroxyvitamin D (25OHD) concentrations have been associated with tumors and osteopenia or fractures in adults with neurofibromatosis type 1 (NF1). We report 25OHD concentrations in 109 children with NF1 and 218 controls matched for age, sex, geographic location, and time of year. METHODS: Children with NF1 were recruited (n=109; 2-17 years), and clinical data and dual-energy X-ray absorptiometry measurements were obtained. 25OHD concentrations were measured in subjects and controls. RESULTS: More NF1 individuals (50%) were in the 25OHD insufficient or deficient range (<30 ng/mL) (1 ng/mL = 2.496 nmol/L) compared to controls (36%) (p = 0.0129). 25OHD concentrations were higher in individuals with neurofibromas after controlling for age (p = 0.0393), and were negatively associated with whole-body subtotal bone mineral density (BMD) z-scores (p = 0.0385). CONCLUSIONS: More children with NF1 had 25OHD concentrations <30 ng/mL, potentially because of increased pigmentation and/or decreased sunlight exposure. In contrast to adults, decreased 25OHD concentrations were not associated with neurofibromas, and there was no positive association between 25OHD and BMD.[1]

References

Pediatric 25-hydroxyvitamin D concentrations in neurofibromatosis type 1. Stevenson, D.A., Viskochil, D.H., Carey, J.C., Sheng, X., Murray, M., Moyer-Mileur, L., Shelton, J., Roberts, W.L., Bunker, A.M., Hanson, H., Bauer, S., D'Astous, J.L. J. Pediatr. Endocrinol. Metab. (2011) [Pubmed]

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