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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The effects of 3-deazaguanine on Rous sarcoma virus transformation.

An expression of cellular transformation in chicken embryo fibroblast infected with Rous sarcoma virus (RSV) was inhibited by 3-deazaguanine (3-DG). Re-transformation of normal rat kidney cells infected with a temperature-sensitive mutant of RSV was suppressed by 3-DG when the cells were shifted from the non-permissive temperature (38 degrees C) to the permissive temperature (33 degrees C). Removal of the inhibitor enabled the cells to revert to the transformed state. Finally, 3-DG had little or no effect on replication of RSV in the chicken embryo fibroblast cells.[1]


  1. The effects of 3-deazaguanine on Rous sarcoma virus transformation. Chen, Y.C., Liu, L.A., Borchardt, K.A. Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi (1990) [Pubmed]
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