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Gene Review

IL8L2  -  interleukin 8-like 2

Gallus gallus

Synonyms: CXCL8, CXCLi2, EMF-1, IL8
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Disease relevance of IL8


High impact information on IL8


Chemical compound and disease context of IL8


Biological context of IL8

  • Sequence comparisons also identify conserved regions in the promoter that may function as transcription factor binding sites as yet undescribed in the human IL8 promoter [15].
  • Analysis of the predicted amino acid sequence suggests that overall protein structure is conserved between human and chicken IL8, but that the receptor binding sites are not [15].
  • DNA sequencing of the 1.2-kilobase insert of CEF-4 revealed an open reading frame that predicts an 11-kDa protein [16].
  • Therefore, transcriptional activation plays an important role in the late, constitutive expression of the CEF-4 gene in stably transformed cells [17].
  • The abundant expression of 9E3 in normal tissues indicates that the product of this gene plays a normal physiological role in tissues growing by cell division, perhaps as a growth regulator [9].

Anatomical context of IL8


Associations of IL8 with chemical compounds

  • A number of chemicals, mostly adenosine analogues, cause the nucleolus of the chick embryo fibroblast to lose material and unravel over a period of several hours into beaded strands termed nucleolar necklaces (NN) [22].
  • Treatment of CEF with agents that modulate cell shape or attachment to the substratum caused an increase in 9E3 mRNA without an increase in tyrosine phosphorylation [23].
  • 9E3 mRNA was also increased in CEF in response to several agents which modulate phosphorylation, including phorbol myristic acetate, vanadate, and okadaic acid, which suggests that the rapid induction of 9E3 mRNA expression in CEF by the src protein occurs downstream of morphological or phosphorylation events [23].
  • Experiments using tunicamycin indicate that the HA made by MDBK cells contains about 4000 daltons of carbohydrate in excess of that on the HA from chick embryo fibroblast [24].
  • The asparagine-linked oligosaccharides of chick embryo fibroblast glycoproteins were previously shown to derive from a common lipid-linked precursor, Glc3Man9GlcNAc2 [25].

Regulatory relationships of IL8


Other interactions of IL8


Analytical, diagnostic and therapeutic context of IL8


  1. Transformation by Rous sarcoma virus induces a novel gene with homology to a mitogenic platelet protein. Sugano, S., Stoeckle, M.Y., Hanafusa, H. Cell (1987) [Pubmed]
  2. Two strains of avian sarcoma virus newly isolated from chick fibrosarcomas induced by lymphatic leukemia virus subgroup A in two lines of chickens. Hihara, H., Shimizu, T., Yamamoto, H., Yoshino, T. J. Natl. Cancer Inst. (1984) [Pubmed]
  3. The akt kinase: molecular determinants of oncogenicity. Aoki, M., Batista, O., Bellacosa, A., Tsichlis, P., Vogt, P.K. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  4. Transformation of chicken embryo fibroblast cells by avian retroviruses containing the human Fyn gene and its mutated genes. Semba, K., Kawai, S., Matsuzawa, Y., Yamanashi, Y., Nishizawa, M., Toyoshima, K. Mol. Cell. Biol. (1990) [Pubmed]
  5. A monoclonal antibody reactive with Marek's disease tumor-associated surface antigen. Lee, L.F., Liu, X., Sharma, J.M., Nazerian, K., Bacon, L.D. J. Immunol. (1983) [Pubmed]
  6. Tumor promoters induce changes in the chick embryo fibroblast cytoskeleton. Rifkin, D.B., Crowe, R.M., Pollack, R. Cell (1979) [Pubmed]
  7. Secretion of a nerve growth factor by primary chick fibroblast cultures. Young, M., Oger, J., Blanchard, M.H., Asdourian, H., Amos, H., Arnason, B.G. Science (1975) [Pubmed]
  8. Successful immunization of children with and without maternal antibody by aerosolized measles vaccine. I. Different results with undiluted human diploid cell and chick embryo fibroblast vaccines. Sabin, A.B., Flores Arechiga, A., Fernández de Castro, J., Sever, J.L., Madden, D.L., Shekarchi, I., Albrecht, P. JAMA (1983) [Pubmed]
  9. Localization of 9E3/CEF-4 in avian tissues: expression is absent in Rous sarcoma virus-induced tumors but is stimulated by injury. Martins-Green, M., Bissell, M.J. J. Cell Biol. (1990) [Pubmed]
  10. Evidence for a guanine nucleotide-binding regulatory protein in invertebrate and mammalian sperm. Identification by islet-activating protein-catalyzed ADP-ribosylation and immunochemical methods. Kopf, G.S., Woolkalis, M.J., Gerton, G.L. J. Biol. Chem. (1986) [Pubmed]
  11. Tumor necrosis factor-alpha but not interleukin-1 beta or interleukin-8 concentrations correlate with angiogenic activity of peritoneal fluid from patients with minimal to mild endometriosis. Maas, J.W., Calhaz-Jorge, C., ter Riet, G., Dunselman, G.A., de Goeij, A.F., Struijker-Boudier, H.A. Fertil. Steril. (2001) [Pubmed]
  12. Comparison of substrate specificities against the fusion glycoprotein of virulent Newcastle disease virus between a chick embryo fibroblast processing protease and mammalian subtilisin-like proteases. Fujii, Y., Sakaguchi, T., Kiyotani, K., Yoshida, T. Microbiol. Immunol. (1999) [Pubmed]
  13. Arginine metabolism in infected cell cultures as a marker character for the differentiation of orthopoxviruses. Osborn, J.G., Chesters, P.M., Williamson, J.D. The Journal of hygiene. (1984) [Pubmed]
  14. The effects of 3-deazaguanine on Rous sarcoma virus transformation. Chen, Y.C., Liu, L.A., Borchardt, K.A. Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi (1990) [Pubmed]
  15. The chicken 9E3/CEF4 CXC chemokine is the avian orthologue of IL8 and maps to chicken chromosome 4 syntenic with genes flanking the mammalian chemokine cluster. Kaiser, P., Hughes, S., Bumstead, N. Immunogenetics (1999) [Pubmed]
  16. Constitutive expression of a gene encoding a polypeptide homologous to biologically active human platelet protein in Rous sarcoma virus-transformed fibroblasts. Bedard, P.A., Alcorta, D., Simmons, D.L., Luk, K.C., Erikson, R.L. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  17. Transcriptional activation of the CEF-4/9E3 cytokine gene by pp60v-src. Dehbi, M., Mbiguino, A., Beauchemin, M., Chatelain, G., Bédard, P.A. Mol. Cell. Biol. (1992) [Pubmed]
  18. Immune responses in Eimeria acervulina infected one-day-old broilers compared to amount of Eimeria in the duodenum, measured by real-time PCR. Swinkels, W.J., Post, J., Cornelissen, J.B., Engel, B., Boersma, W.J., Rebel, J.M. Vet. Parasitol. (2006) [Pubmed]
  19. Assembly of different isoforms of actin and tropomyosin into the skeletal tropomyosin-enriched microfilaments during differentiation of muscle cells in vitro. Lin, J.J., Lin, J.L. J. Cell Biol. (1986) [Pubmed]
  20. Expression of the oncogene of avian reticuloendotheliosis virus in Escherichia coli and identification of the transforming protein in reticuloendotheliosis virus T-transformed cells. Herzog, N.K., Bose, H.R. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  21. Novel tenascin variants with a distinctive pattern of expression in the avian embryo. Tucker, R.P., Spring, J., Baumgartner, S., Martin, D., Hagios, C., Poss, P.M., Chiquet-Ehrismann, R. Development (1994) [Pubmed]
  22. Nucleolar necklaces in chick embryo fibroblast cells. I. Formation of necklaces by dichlororibobenzimidazole and other adenosine analogues that decrease RNA synthesis and degrade preribosomes. Granick, D. J. Cell Biol. (1975) [Pubmed]
  23. Expression of 9E3 mRNA is associated with mitogenicity, phosphorylation, and morphological alteration in chicken embryo fibroblasts. Barker, K., Hanafusa, H. Mol. Cell. Biol. (1990) [Pubmed]
  24. Oligosaccharide composition of an influenza virus hemagglutinin with host-determined binding properties. Deom, C.M., Schulze, I.T. J. Biol. Chem. (1985) [Pubmed]
  25. Synthesis of the N-linked oligosaccharides of glycoproteins. Assembly of the lipid-linked precursor oligosaccharide and its relation to protein synthesis in vivo. Hubbard, S.C., Robbins, P.W. J. Biol. Chem. (1980) [Pubmed]
  26. A proteolytic fragment of insulin-like growth factor (IGF) binding protein-3 that fails to bind IGF is a cell growth inhibitor. Lalou, C., Lassarre, C., Binoux, M. Prog. Growth Factor Res. (1995) [Pubmed]
  27. The sequence of chick alpha-actinin reveals homologies to spectrin and calmodulin. Baron, M.D., Davison, M.D., Jones, P., Critchley, D.R. J. Biol. Chem. (1987) [Pubmed]
  28. Chicken proto-oncogene c-ros cDNA clones: identification of a c-ros RNA transcript and deduction of the amino acid sequence of the carboxyl terminus of the c-ros product. Podell, S.B., Sefton, B.M. Oncogene (1987) [Pubmed]
  29. Cloning and characterization of a novel sequence-specific single-stranded-DNA-binding protein. Bayarsaihan, D., Soto, R.J., Lukens, L.N. Biochem. J. (1998) [Pubmed]
  30. Blockage of antiviral induction of interferon by homologous cell biochemical activity: effect of chicken embryo fibroblast mitotic cell cycle phases on Sindbis virus growth. Ghubril, V.A. J. Virol. (1983) [Pubmed]
  31. Properties of a chicken lymphoblastoid cell line from Marek's disease tumor. Nazerian, K., Witter, R.L. J. Natl. Cancer Inst. (1975) [Pubmed]
  32. Intranasal administration of chick embryo fibroblast Edmonston-Zagreb measles vaccine. Vlatkovic, R., Smerdel, S., Gvojic, B., Manhalter, T., Beck, M., Weisz-Malecek, R., Delimar, N. Lancet (1985) [Pubmed]
  33. Identification of a new protein localized at sites of cell-substrate adhesion. Beckerle, M.C. J. Cell Biol. (1986) [Pubmed]
  34. AFAP-120. A variant form of the Src SH2/SH3-binding partner AFAP-110 is detected in brain and contains a novel internal sequence which binds to a 67-kDa protein. Flynn, D.C., Koay, T.C., Humphries, C.G., Guappone, A.C. J. Biol. Chem. (1995) [Pubmed]
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