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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Acute dystonia during fixed-dose neuroleptic treatment.

Eighty-six patients with acute psychotic exacerbations were treated with fixed dosage regimens of oral fluphenazine up to 10-30 mg/day in randomized, double-blind studies. Dystonic reactions occurred in 33.8% of the subjects at risk. Of these, 58% occurred by the third day, 88% by the fourth day, and 100% by the ninth day of treatment; most occurred later in the interdose interval. Significant predictors of dystonic reactions were higher fluphenazine mg/kg dosage and younger age. There was a trend toward a lower risk of dystonia in patients who received amobarbital sodium for agitation. Results are discussed in relation to possible mechanisms of neuroleptic-induced dystonia.[1]


  1. Acute dystonia during fixed-dose neuroleptic treatment. Singh, H., Levinson, D.F., Simpson, G.M., Lo, E.S., Friedman, E. Journal of clinical psychopharmacology. (1990) [Pubmed]
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