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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Characteristics and postnatal development of the acid lipase activity of the rat small intestine.

Acid lipase was identified in the rat small intestine by using esters of 4-methylumbelliferone as substrates. Maximum activity towards the oleate ester was found at pH 4. 0. In adult animals, the activity of acid lipase exhibited both latency and sedimentability, indicating a lyosomal localization. The activity of acid lipase was practically the same along the height of the villus, thus paralleling the distribution of acid beta-galactosidase. In adult rats, the activity of acid lipase in proximal (jejunum) and middle (mid-jejunum) sections of the small intestine was practically the same and exceeded the activity in the distal (ileum) section by a factor of 2. In suckling rats, the activity of the enzyme in the mid-jejunum exceeded that in the jejunum and ileum by 2.5- and 1.5-fold respectively. During postnatal development, the acid lipase activity of the mid-jejunum showed a peak between days 10 and 15, at which time it exceeded the adult mid-jejunum activity by 5--6-fold.[1]


  1. Characteristics and postnatal development of the acid lipase activity of the rat small intestine. Coates, P.M., Brown, S.A., Jumawan, J., Koldovský, O. Biochem. J. (1977) [Pubmed]
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