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Bannatyne, R.M. et al.

Protective effect of polymyxin B sulfate in experimental enterobacterial infection in mice.

The mouse model of intraperitoneal enterobacterial sepsis was used to evaluate the anti-endotoxic effect of polymyxin B sulfate. Single or multiple therapeutic doses of polymyxin, administered either before or after lethal challenge with Serratia marcescens, produced statistically and clinically significant protective effects.[1]

References

Protective effect of polymyxin B sulfate in experimental enterobacterial infection in mice. Bannatyne, R.M., Cheung, R. Can. J. Microbiol. (1979) [Pubmed]

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