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MeSH Review


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Disease relevance of Serratia


High impact information on Serratia

  • Crystal structure of a GCN5-related N-acetyltransferase: Serratia marcescens aminoglycoside 3-N-acetyltransferase [6].
  • Superattenuation in the tryptophan operon of Serratia marcescens [1].
  • Investigation suggested that pediatric-sized vacuum tubes containing ethylenediamine tetraacetic acid (EDTA) were the source of the organisms, and the epidemic strain of Serratia was recovered from 41 (35%) of the 116 tubes cultured [7].
  • When anti-Gal bound onto the lipopolysaccharide of a representative blood isolate, Serratia marcescens #21, it blocked its alternative complement pathway (ACP) lysis and made the organism serum resistant [8].
  • In contrast, when anti-Gal bound to the capsular polysaccharide of a serum sensitive Serratia, #7, it increased ACP killing of this strain [8].

Chemical compound and disease context of Serratia

  • The mechanism of blockade of ACP lysis by anti-Gal did not involve a decrease in the number of C3 molecules deposited onto Serratia #21 or an inhibition of the binding of C3b to its LPS, nor did it change the iC3b and C3d degradation products of bound C3b or prevent membrane attack complex formation on this organism [8].
  • Gentamicin-resistant Serratia [9].
  • Serratia sensitivity to ampicillin and tetracycline was an epidemiological marker of a common-source outbreak [10].
  • The crystal structure of anthranilate synthase (AS) from Serratia marcescens, a mesophilic bacterium, has been solved in the presence of its substrates, chorismate and glutamine, and one product, glutamate, at 1.95 A, and with its bound feedback inhibitor, tryptophan, at 2.4 A [11].
  • The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan [11].

Biological context of Serratia


Anatomical context of Serratia

  • Treatment of Serratia polyribosomes with RNase or pronase reduced the number of survivors [17].
  • We evaluated the safety, efficacy, and microbiologic activity of combination amdinocillin and cefoxitin treatment in 17 patients with complicated urinary tract infections caused by multiply-resistant Serratia marcescens [18].
  • Lysozyme-tris-EDTA spheroplast preparations of the Serratia isolates were also tested for potassium ion leakage following exposure to chlorhexidine and it was found that the inner membrane was responsible for the decreased susceptibility of the organism of chlorhexidine [19].
  • The anticomplement properties of two chromatographically distinct fractions of a phenol-extracted lipopolysaccharide isolated from Serratia marcescens were assessed by means of the standard sheep erythrocyte hemolytic assay and an alternative pathway-selective kinetic assay using rabbit erythrocytes [20].
  • Substrates with extreme structural features, like poly(dA).poly(dT) or poly(dG).poly(dC), are cleaved by the Serratia nuclease with a 50 times higher or 10 times lower K(m), respectively, as salmon testis DNA [21].

Gene context of Serratia

  • The cecropin genes were also induced when the flies were kept on food with the Drosophila pathogenic bacterium Serratia marcescens Db10 or its non-pathogenic derivative Db1140 [22].
  • Flow cytometric studies, using a panel of monoclonal antibodies (MoAbs), showed that Serratia marcescens protease treatment removed greater than 97% of the glycocalicin portion of GPIb but did not affect the changes in the expression of GPIX or GMP-140 that were induced by high concentrations of alpha-thrombin (10 nmol/L) [13].
  • Experiments with Serratia protease-treated and Bernard-Soulier platelets showed that neither platelet surface GPIb nor cathepsin G-induced proteolysis of GPIb were required for the cathepsin G-induced redistribution of the remnant of the GPIb-IX complex or the cathepsin G-induced increase in platelet surface P-selectin [23].
  • Three distinct fragments, the 38-kDa fragment produced by Serratia marcescens protease as well as the 45- and 35-kDa fragments produced by trypsin, had the same NH2 terminus as the intact GPIb alpha-chain (apparent molecular mass = 140 kDa) [24].
  • The regulatory significance of these sequence features is discussed with respect to the rbs operon. rbsK has been cloned downstream from the Serratia marcescens trp promoter on a multicopy plasmid [25].

Analytical, diagnostic and therapeutic context of Serratia


  1. Superattenuation in the tryptophan operon of Serratia marcescens. Stroynowski, I., van Cleemput, M., Yanofsky, C. Nature (1982) [Pubmed]
  2. Antibody production in vitamin A-depleted rats is impaired after immunization with bacterial polysaccharide or protein antigens. Pasatiempo, A.M., Kinoshita, M., Taylor, C.E., Ross, A.C. FASEB J. (1990) [Pubmed]
  3. Purification and properties of a third form of anthranilate-5-phosphoribosylpyrophosphate phosphoribosyltransferase from the Enterobacteriaceae. Largen, M., Mills, S.E., Rowe, J., Yanofsky, C. J. Biol. Chem. (1978) [Pubmed]
  4. Carbapenems: special properties contributing to their activity. Neu, H.C. Am. J. Med. (1985) [Pubmed]
  5. New beta-lactam antibiotics in granulocytopenic patients. New options and new questions. Pizzo, P.A., Thaler, M., Hathorn, J., Hiemenz, J., Skelton, J., McKnight, J., Rubin, M., Browne, M., Longo, D., Cotton, D. Am. J. Med. (1985) [Pubmed]
  6. Crystal structure of a GCN5-related N-acetyltransferase: Serratia marcescens aminoglycoside 3-N-acetyltransferase. Wolf, E., Vassilev, A., Makino, Y., Sali, A., Nakatani, Y., Burley, S.K. Cell (1998) [Pubmed]
  7. False-positive blood cultures. Association with nonsterile blood collection tubes. Hoffman, P.C., Arnow, P.M., Goldmann, D.A., Parrott, P.L., Stamm, W.E., McGowan, J.E. JAMA (1976) [Pubmed]
  8. Human natural anti-Gal IgG regulates alternative complement pathway activation on bacterial surfaces. Hamadeh, R.M., Jarvis, G.A., Galili, U., Mandrell, R.E., Zhou, P., Griffiss, J.M. J. Clin. Invest. (1992) [Pubmed]
  9. Gentamicin-resistant Serratia. Severn, M. Lancet (1977) [Pubmed]
  10. Antibiotic-sensitive Serratia marcescens infections complicating cardiopulmonary operations: contaminated disinfectant as a reservoir. Ehrenkranz, N.J., Bolyard, E.A., Wiener, M., Cleary, T.J. Lancet (1980) [Pubmed]
  11. The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan. Spraggon, G., Kim, C., Nguyen-Huu, X., Yee, M.C., Yanofsky, C., Mills, S.E. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  12. DNA sequence of the Serratia marcescens lipoprotein gene. Nakamura, K., Inouye, M. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  13. Glycoprotein Ib (GPIb)-dependent and GPIb-independent pathways of thrombin-induced platelet activation. Yamamoto, N., Greco, N.J., Barnard, M.R., Tanoue, K., Yamazaki, H., Jamieson, G.A., Michelson, A.D. Blood (1991) [Pubmed]
  14. Human fibroblast collagenase contains an amino acid sequence homologous to the zinc-binding site of Serratia protease. McKerrow, J.H. J. Biol. Chem. (1987) [Pubmed]
  15. Properties of hybrid aspartate transcarbamoylase formed with native subunits from divergent bacteria. Shanley, M.S., Foltermann, K.F., O'Donovan, G.A., Wild, J.R. J. Biol. Chem. (1984) [Pubmed]
  16. Isolation and characterization of mutants affecting functional domains of ColE1 RNAI. Dooley, T.P., Tamm, J., Polisky, B. J. Mol. Biol. (1985) [Pubmed]
  17. Tumor-immunotherapeutic efficacy of Serratia marcescens polyribosomes. Urban, R.W., Edwards, B.S., Segal, W. Cancer Res. (1980) [Pubmed]
  18. Combination amdinocillin and cefoxitin therapy of multiply-resistant Serratia marcescens urinary tract infections. Ward, T.T., Amon, M.B., Krause, L.K. Am. J. Med. (1983) [Pubmed]
  19. Decreased susceptibility of Serratia marcescens to chlorhexidine related to the inner membrane. Lannigan, R., Bryan, L.E. J. Antimicrob. Chemother. (1985) [Pubmed]
  20. Evidence for different requirements in physical state for the interaction of lipopolysaccharides with the classical and alternative pathways of complement. Wilson, M.E., Morrison, D.C. Eur. J. Biochem. (1982) [Pubmed]
  21. Kinetic analysis of the cleavage of natural and synthetic substrates by the Serratia nuclease. Friedhoff, P., Meiss, G., Kolmes, B., Pieper, U., Gimadutdinow, O., Urbanke, C., Pingoud, A. Eur. J. Biochem. (1996) [Pubmed]
  22. The cecropin locus in Drosophila; a compact gene cluster involved in the response to infection. Kylsten, P., Samakovlis, C., Hultmark, D. EMBO J. (1990) [Pubmed]
  23. Neutrophil cathepsin G modulates the platelet surface expression of the glycoprotein (GP) Ib-IX complex by proteolysis of the von Willebrand factor binding site on GPIb alpha and by a cytoskeletal-mediated redistribution of the remainder of the complex. LaRosa, C.A., Rohrer, M.J., Benoit, S.E., Barnard, M.R., Michelson, A.D. Blood (1994) [Pubmed]
  24. The von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Characterization by monoclonal antibodies and partial amino acid sequence analysis of proteolytic fragments. Handa, M., Titani, K., Holland, L.Z., Roberts, J.R., Ruggeri, Z.M. J. Biol. Chem. (1986) [Pubmed]
  25. Ribokinase from Escherichia coli K12. Nucleotide sequence and overexpression of the rbsK gene and purification of ribokinase. Hope, J.N., Bell, A.W., Hermodson, M.A., Groarke, J.M. J. Biol. Chem. (1986) [Pubmed]
  26. Ligand delivery by haem carrier proteins: the binding of Serratia marcescens haemophore to its outer membrane receptor is mediated by two distinct peptide regions. Létoffé, S., Debarbieux, L., Izadi, N., Delepelaire, P., Wandersman, C. Mol. Microbiol. (2003) [Pubmed]
  27. Involvement of N-acyl-L-hormoserine lactone autoinducers in controlling the multicellular behaviour of Serratia liquefaciens. Eberl, L., Winson, M.K., Sternberg, C., Stewart, G.S., Christiansen, G., Chhabra, S.R., Bycroft, B., Williams, P., Molin, S., Givskov, M. Mol. Microbiol. (1996) [Pubmed]
  28. Cloning and sequence analysis of the gene for a carbapenem-hydrolyzing class A beta-lactamase, Sme-1, from Serratia marcescens S6. Naas, T., Vandel, L., Sougakoff, W., Livermore, D.M., Nordmann, P. Antimicrob. Agents Chemother. (1994) [Pubmed]
  29. Multicenter comparison of in vitro activities of FK-037, cefepime, ceftriaxone, ceftazidime, and cefuroxime. Washington, J.A., Jones, R.N., Gerlach, E.H., Murray, P.R., Allen, S.D., Knapp, C.C. Antimicrob. Agents Chemother. (1993) [Pubmed]
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