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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Protein C deficiency associated with massive cerebral thrombosis following open heart surgery.

We describe a case of massive cerebral venous thrombosis following open heart surgery in a patient with a reduced level of Protein C (40% of mean level). Protein C deficiency is an inherited disorder which in the homozygous form may result in massive fatal venous thrombosis in the newborn. A Protein C level below 55% is highly suggestive of heterozygous deficiency and has been associated with a tendency to venous thrombosis although its clinical penetrance is variable. This is the first reported case of massive venous thrombosis in a patient following open heart surgery associated with Protein C deficiency.[1]

References

  1. Protein C deficiency associated with massive cerebral thrombosis following open heart surgery. Ridley, P.D., Ledingham, S.J., Lennox, S.C., Burman, J.F., Chung, H.I., Sheffield, E.A., Talbot, S., Bevan, D. The Journal of cardiovascular surgery. (1990) [Pubmed]
 
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