Efficacy and safety of mercuric oxide in the treatment of bacterial blepharitis.
A double-masked, placebo-controlled, randomized study was done to assess the safety and clinical and quantitative microbiologic efficacy of 1% mercuric oxide (yellow) ophthalmic ointment in the treatment of eyelid infections, i.e., bacterial blepharitis. A total of 39 patients with bacterial counts and clinical signs indicative of eyelid infection were treated twice daily for 7 days. Clinical biomicroscopic examination and quantitative microbiologic cultures were done just prior to initiation of treatment and again on days 3 and 7. Statistical analysis revealed a significant improvement in the clinical signs, bacterial count, cure rate, and improvement rate for subjects taking the active medication, compared with those taking the placebo on days 3 and 7. In addition, the medication was well tolerated.[1]References
- Efficacy and safety of mercuric oxide in the treatment of bacterial blepharitis. Hyndiuk, R.A., Burd, E.M., Hartz, A. Antimicrob. Agents Chemother. (1990) [Pubmed]
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