The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Colony Count, Microbial

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Colony Count, Microbial

  • Significant reductions in bacterial counts and increases in cure rates were observed when clarithromycin at 50 or 100 mg/kg of body weight was combined with 14-hydroxy-clarithromycin at 12 mg/kg or higher [1].
  • Splenic bacterial counts were also amplified by anti-L3T4 antibody when the antibody was injected at the chronic phase, whereas cyclosporin A had an effect only during the initial 6 weeks after BCG infection [2].
  • Wild-type and AQP4-deficient mice had comparable immune responses as measured by brain abscess volume (approximately 3.7 mm3 at 3 days), bacterial count and cytokine levels in brain homogenates [3].
  • Compared with vancomycin, ME1036 reduced the bacterial counts in the vegetations at a lower dosage or over a shorter period of administration when it was used for the treatment of MRSA endocarditis [4].
  • After 1 day the bacterial count of Helicobacter pylori in the presence of omeprazole 200 mg/L was reduced from 10(4) cfu/mL for the control to zero [5].

High impact information on Colony Count, Microbial

  • In alphaC5aR-treated mice, serum levels of IL-6 and TNF-alpha and bacterial counts in various organs were significantly reduced during CLP when compared with control CLP animals [6].
  • The rate of mucociliary clearance and of intrapulmonary bacterial killing (Kk + Kmc) was calculated from the change in bacterial counts with time in animals that had received tetracycline to inhibit bacterial multiplication [7].
  • Imipenem and ciprofloxacin significantly reduced the number of infected pancreatic specimens, bacterial counts, and identified species at 1 week [8].
  • Luminal bacteria or their cell wall polymers were implicated in the pathogenesis of the lesions because sham-operated rats and rats with self-emptying blind loops, having only slightly increased bacterial counts, did not develop hepatic injury [9].
  • No significant differences in intragastric bacterial counts or bacterial species or in intragastric nitrite or N-nitroso-compound concentrations were found as a result of cimetidine treatment [10].

Chemical compound and disease context of Colony Count, Microbial


Biological context of Colony Count, Microbial


Anatomical context of Colony Count, Microbial


Associations of Colony Count, Microbial with chemical compounds


Gene context of Colony Count, Microbial

  • Furthermore, 1000-fold higher bacterial counts at 48 h after infection with S. pneumoniae and, particularly, 50-fold higher pulmonary levels of IL-10 were observed in influenza-recovered mice than in control mice [31].
  • Administration of anti-IL-18 Abs caused a 100- to 1000-fold increase in bacterial counts in the spleen of infected mice but did not change IFN-gamma production levels [32].
  • Serum tumor necrosis factor-alpha (TNF alpha) levels and bacterial counts in blood and organs (liver, spleen, heart, and brain) were similar in H22-treated animals and controls [33].
  • However, interleukin (IL)-8 levels in infected BALF from children with CF were markedly elevated compared with levels in infected and uninfected controls, even after standardization of IL-8 concentrations to bacterial counts [34].
  • Up to 5 weeks after infection with either the highly virulent M. avium strain TMC724 or the intermediately virulent M. avium strain SE01, bacterial counts in the liver, spleen, and lung of p55(-/-) mice were identical to or lower than those in infected p55(+/+) mice [35].

Analytical, diagnostic and therapeutic context of Colony Count, Microbial


  1. Enhancement of the in vitro and in vivo activities of clarithromycin against Haemophilus influenzae by 14-hydroxy-clarithromycin, its major metabolite in humans. Hardy, D.J., Swanson, R.N., Rode, R.A., Marsh, K., Shipkowitz, N.L., Clement, J.J. Antimicrob. Agents Chemother. (1990) [Pubmed]
  2. Mechanisms of recrudescence of Mycobacterium bovis BCG infection in mice. Cox, J.H., Knight, B.C., Ivanyi, J. Infect. Immun. (1989) [Pubmed]
  3. Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess. Bloch, O., Papadopoulos, M.C., Manley, G.T., Verkman, A.S. J. Neurochem. (2005) [Pubmed]
  4. Therapeutic effect of ME1036 on endocarditis experimentally induced by methicillin-resistant Staphylococcus aureus. Nagura, J., Kijima, K., Kurazono, M., Takahata, S., Sugano, T., Tanaka, Y., Hirai, Y., Yamada, K., Takayama, Y., Shitara, E., Yonezawa, M. Antimicrob. Agents Chemother. (2005) [Pubmed]
  5. Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro. Jonkers, D., Stobberingh, E., Stockbrügger, R. J. Antimicrob. Chemother. (1996) [Pubmed]
  6. Increased C5a receptor expression in sepsis. Riedemann, N.C., Guo, R.F., Neff, T.A., Laudes, I.J., Keller, K.A., Sarma, V.J., Markiewski, M.M., Mastellos, D., Strey, C.W., Pierson, C.L., Lambris, J.D., Zetoune, F.S., Ward, P.A. J. Clin. Invest. (2002) [Pubmed]
  7. Determinants of lung bacterial clearance in normal mice. Jay, S.J., Johanson, W.G., Pierce, A.K., Reisch, J.S. J. Clin. Invest. (1976) [Pubmed]
  8. Antibiotic treatment improves survival in experimental acute necrotizing pancreatitis. Mithöfer, K., Fernández-del Castillo, C., Ferraro, M.J., Lewandrowski, K., Rattner, D.W., Warshaw, A.L. Gastroenterology (1996) [Pubmed]
  9. Hepatic injury associated with small bowel bacterial overgrowth in rats is prevented by metronidazole and tetracycline. Lichtman, S.N., Keku, J., Schwab, J.H., Sartor, R.B. Gastroenterology (1991) [Pubmed]
  10. Intragastric acidity, bacteria, nitrite, and N-nitroso compounds before, during, and after cimetidine treatment. Milton-Thompson, G.J., Lightfoot, N.F., Ahmet, Z., Hunt, R.H., Barnard, J., Bavin, P.M., Brimblecombe, R.W., Darkin, D.W., Moore, P.J., Viney, N. Lancet (1982) [Pubmed]
  11. Efficacy of linezolid plus rifampin in an experimental model of methicillin-susceptible Staphylococcus aureus endocarditis. Dailey, C.F., Pagano, P.J., Buchanan, L.V., Paquette, J.A., Haas, J.V., Gibson, J.K. Antimicrob. Agents Chemother. (2003) [Pubmed]
  12. Experimental pneumococcal pleural empyema model: the effect of moxifloxacin. Strahilevitz, J., Lev, A., Levi, I., Fridman, E., Rubinstein, E. J. Antimicrob. Chemother. (2003) [Pubmed]
  13. Staphylococcal osteomyelitis--a comparison of co-amoxiclav with clindamycin and flucloxacillin in an experimental rat model. Gisby, J., Beale, A.S., Bryant, J.E., Toseland, C.D. J. Antimicrob. Chemother. (1994) [Pubmed]
  14. The mutagenic activity of gastric juice. O'Connor, H.J., Riley, S.E., Axon, A.T., Dixon, M.F., Girling, A., Garner, R.C. Mutat. Res. (1988) [Pubmed]
  15. Association between fecal hydrogen sulfide production and pouchitis. Ohge, H., Furne, J.K., Springfield, J., Rothenberger, D.A., Madoff, R.D., Levitt, M.D. Dis. Colon Rectum (2005) [Pubmed]
  16. Fas ligand-induced apoptosis of infected human macrophages reduces the viability of intracellular Mycobacterium tuberculosis. Oddo, M., Renno, T., Attinger, A., Bakker, T., MacDonald, H.R., Meylan, P.R. J. Immunol. (1998) [Pubmed]
  17. Pharmacodynamics of levofloxacin and ciprofloxacin against Streptococcus pneumoniae. Lister, P.D., Sanders, C.C. J. Antimicrob. Chemother. (1999) [Pubmed]
  18. Treatment of septic shock with a protease inhibitor in a canine model: a prospective, randomized, controlled trial. Tani, T., Aoki, H., Yoshioka, T., Lin, K.J., Kodama, M. Crit. Care Med. (1993) [Pubmed]
  19. Dental unit waterline contamination and its possible implications during periodontal surgery. Putnins, E.E., Di Giovanni, D., Bhullar, A.S. J. Periodontol. (2001) [Pubmed]
  20. Mutans streptococci, lactobacilli and caries experience in cystic fibrosis homozygotes, heterozygotes and healthy controls. Aps, J.K., Van Maele, G.O., Claeys, G., Martens, L.C. Caries Res. (2001) [Pubmed]
  21. Norfloxacin in the treatment of urinary tract infections in men with and without identifiable urologic complications. Corrado, M.L., Grad, C., Sabbaj, J. Am. J. Med. (1987) [Pubmed]
  22. Automated flow cytometry compared with an automated dipstick reader for urinalysis. Langlois, M.R., Delanghe, J.R., Steyaert, S.R., Everaert, K.C., De Buyzere, M.L. Clin. Chem. (1999) [Pubmed]
  23. Experimental study of LY333328 (oritavancin), alone and in combination, in therapy of cephalosporin-resistant pneumococcal meningitis. Cabellos, C., Fernàndez, A., Maiques, J.M., Tubau, F., Ardanuy, C., Viladrich, P.F., Liñares, J., Gudiol, F. Antimicrob. Agents Chemother. (2003) [Pubmed]
  24. In vitro activity of sparfloxacin (CI-978; AT-4140) for clinical Legionella isolates, pharmacokinetics in guinea pigs, and use to treat guinea pigs with L. pneumophila pneumonia. Edelstein, P.H., Edelstein, M.A., Weidenfeld, J., Dorr, M.B. Antimicrob. Agents Chemother. (1990) [Pubmed]
  25. Development of an interleukin-12-deficient mouse model that is permissive for colonization by a motile KE26695 strain of Helicobacter pylori. Hoffman, P.S., Vats, N., Hutchison, D., Butler, J., Chisholm, K., Sisson, G., Raudonikiene, A., Marshall, J.S., Veldhuyzen van Zanten, S.J. Infect. Immun. (2003) [Pubmed]
  26. Effect of cimetidine on the gastric bacterial flora. Ruddell, W.S., Axon, A.T., Findlay, J.M., Bartholomew, B.A., Hill, M.J. Lancet (1980) [Pubmed]
  27. Is skin preparation necessary before insulin injection? Koivisto, V.A., Felig, P. Lancet (1978) [Pubmed]
  28. Effect of omeprazole on intragastric bacterial counts, nitrates, nitrites, and N-nitroso compounds. Verdu, E., Viani, F., Armstrong, D., Fraser, R., Siegrist, H.H., Pignatelli, B., Idström, J.P., Cederberg, C., Blum, A.L., Fried, M. Gut (1994) [Pubmed]
  29. Therapeutic efficacy of fleroxacin for eliminating catheter-associated urinary tract infection in a rabbit model. Morck, D.W., Olson, M.E., McKay, S.G., Lam, K., Prosser, B., Cleeland, R., Costerton, J.W. Am. J. Med. (1993) [Pubmed]
  30. Effects of one year's treatment with ranitidine and of truncal vagotomy on gastric contents. Thomas, J.M., Misiewicz, J.J., Cook, A.R., Hill, M.J., Smith, P.L., Walters, C.L., Forster, J.K., Martin, L.E., Woodings, D.F. Gut (1987) [Pubmed]
  31. IL-10 is an important mediator of the enhanced susceptibility to pneumococcal pneumonia after influenza infection. van der Sluijs, K.F., van Elden, L.J., Nijhuis, M., Schuurman, R., Pater, J.M., Florquin, S., Goldman, M., Jansen, H.M., Lutter, R., van der Poll, T. J. Immunol. (2004) [Pubmed]
  32. IL-18 (IFN-gamma-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice. Bohn, E., Sing, A., Zumbihl, R., Bielfeldt, C., Okamura, H., Kurimoto, M., Heesemann, J., Autenrieth, I.B. J. Immunol. (1998) [Pubmed]
  33. Role of interferon-gamma in experimental gram-negative sepsis. Silva, A.T., Cohen, J. J. Infect. Dis. (1992) [Pubmed]
  34. Nasal and bronchoalveolar lavage fluid cytokines in early cystic fibrosis. Noah, T.L., Black, H.R., Cheng, P.W., Wood, R.E., Leigh, M.W. J. Infect. Dis. (1997) [Pubmed]
  35. Fatal granuloma necrosis without exacerbated mycobacterial growth in tumor necrosis factor receptor p55 gene-deficient mice intravenously infected with Mycobacterium avium. Ehlers, S., Benini, J., Kutsch, S., Endres, R., Rietschel, E.T., Pfeffer, K. Infect. Immun. (1999) [Pubmed]
  36. Caspase-1 inhibitor reduces severity of pseudomonas aeruginosa keratitis in mice. Thakur, A., Barrett, R.P., Hobden, J.A., Hazlett, L.D. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  37. Ventilator-associated pneumonia: Increased bacterial counts in bronchoalveolar lavage by using urea as an endogenous marker of dilution. Zedtwitz-Liebenstein, K., Schenk, P., Apfalter, P., Fuhrmann, V., Stoiser, B., Graninger, W., Schuster, E., Frass, M., Burgmann, H. Crit. Care Med. (2005) [Pubmed]
  38. Congenital immunodeficiencies in mice increase susceptibility to urinary tract infection. Hopkins, W.J., James, L.J., Balish, E., Uehling, D.T. J. Urol. (1993) [Pubmed]
  39. The diagnosis of small bowel bacterial overgrowth in elderly patients. Donald, I.P., Kitchingmam, G., Donald, F., Kupfer, R.M. Journal of the American Geriatrics Society. (1992) [Pubmed]
  40. Speed of change in pancreatic mass and in intestinal bacteriology of parenterally fed rats. Hughes, C.A., Prince, A., Dowling, R.H. Clin. Sci. (1980) [Pubmed]
WikiGenes - Universities