Disease relevance of Blepharitis

• NFAT mutant mice also have allergic blepharitis, interstitial pneumonitis, and a 10(3) to 10(4) fold increase in serum IgG1 and IgE levels, secondary to a dramatic and selective increase in Th2 cytokines [1].
• PURPOSE: In contrast to wild-type mice, genetically engineered Mucin1 (Muc1) null animals display a marked propensity for development of blepharitis and conjunctivitis [2].
• Relation of cholesterol-stimulated Staphylococcus aureus growth to chronic blepharitis [3].
• The authors tested this hypothesis by examining the differential effect of tetracycline on growth and lipase production in a tetracycline-resistant and tetracycline-sensitive strain of Staphylococcus epidermidis and S. aureus isolated from patients with MKC and Staphylococcal blepharitis [4].
• CONCLUSION: Metronidazole topical gel may be a safe and effective means of treating rosacea blepharitis [5].

High impact information on Blepharitis

• Blepharitis and clinical signs of infection were evident in IFN-alpha/betaR-/- and IFN-alpha/beta/gammaR-/- but not control mice for all viruses [6].
• Periocular inflammation in mice with experimental systemic lupus erythematosus. A new experimental blepharitis and its modulation [7].
• The 5gP DNA-vaccinated mice had less blepharitis and latency than any other group and had the highest levels of IL-12 and IFN-gamma [8].
• Enhanced secretory group II PLA2 activity in the tears of chronic blepharitis patients [9].
• The role of wax and sterol ester fatty acids in chronic blepharitis [10].

Chemical compound and disease context of Blepharitis

• The role of cholesterol in chronic blepharitis [11].
• Efficacy and safety of mercuric oxide in the treatment of bacterial blepharitis [12].
• The role of tetracycline in chronic blepharitis. Inhibition of lipase production in staphylococci [4].
• Cystic fibrosis patients showed a statistically significant increase in the incidence of fluorescein staining and clinical blepharitis, as well as significantly decreased Schirmer testing and tear lysozyme [13].
• Commonly reported adverse events were headache, increased sweating, nausea, and vomiting in the pilocarpine group, while one patient in the inferior puncta occlusion group had blepharitis and was withdrawn from the study [14].

Biological context of Blepharitis

• CONCLUSION: NAC is thought to increase FBUT and improve mucous fern pattern by blocking lipid peroxidation in chronic blepharitis [15].

Anatomical context of Blepharitis

• The objective of this research was to determine the effect of oral minocycline on the meibomian gland nonpolar and free fatty acid lipids of chronic blepharitis patients [16].
• The results of this study suggest that hypersensitivity to the S aureus cell wall, and particularly the ribitol teichoic acid that it contains, plays a role in the pathogenesis of staphylococcal blepharitis [17].
• Many of these problems can be readily treated, including myopia, blepharitis, nasolacrimal duct obstruction, and ptosis [18].

Gene context of Blepharitis

• Granulomatous blepharitis as a sign of Melkersson-Rosenthal syndrome [19].
• Lymphadenopathy, eczema, influenza, herpes, crusts behind ears, blepharitis, seborrhea, psoriasis, erythema, vitiligo, secondary infections, and scars were equally common in both groups [20].
• CF patients showed a statistically significant increase in the incidence of clinical blepharitis [21].
• The prevalence of Staphylococcus aureus, which was considerable in the pre-antibiotic era, has markedly decreased, although a distinct entity of staphylococcal blepharitis seems to remain, either alone or in combination with seborrheic blepharitis (62.8% of our patients) [22].
• DATA SYNTHESIS: Antibiotics are often prescribed for months or even years for treatment of chronic inflammatory conditions such as acne, blepharitis, cardiovascular disease, cystic fibrosis, periodontitis, rosacea, and rheumatoid arthritis [23].

Analytical, diagnostic and therapeutic context of Blepharitis

• RESULTS: A polar lipid with an HPLC retention time longer than either phosphatidylcholine or sphingomyelin and shorter than phosphatidylethanolamine was significantly greater in the meibomianitis group (P<0.05) compared with other chronic blepharitis groups and normals [24].
• Thirty-nine patients with bacterial ocular surface infections (conjunctivitis, blepharitis or blepharoconjunctivitis) were evaluated after treatment with a topically applied ophthalmic solution containing trimethoprim [25].

References