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Disease relevance of Blepharitis


High impact information on Blepharitis

  • Blepharitis and clinical signs of infection were evident in IFN-alpha/betaR-/- and IFN-alpha/beta/gammaR-/- but not control mice for all viruses [6].
  • Periocular inflammation in mice with experimental systemic lupus erythematosus. A new experimental blepharitis and its modulation [7].
  • The 5gP DNA-vaccinated mice had less blepharitis and latency than any other group and had the highest levels of IL-12 and IFN-gamma [8].
  • Enhanced secretory group II PLA2 activity in the tears of chronic blepharitis patients [9].
  • The role of wax and sterol ester fatty acids in chronic blepharitis [10].

Chemical compound and disease context of Blepharitis


Biological context of Blepharitis


Anatomical context of Blepharitis


Gene context of Blepharitis


Analytical, diagnostic and therapeutic context of Blepharitis


  1. Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development. Ranger, A.M., Oukka, M., Rengarajan, J., Glimcher, L.H. Immunity (1998) [Pubmed]
  2. Bacterial conjunctivitis in Muc1 null mice. Kardon, R., Price, R.E., Julian, J., Lagow, E., Tseng, S.C., Gendler, S.J., Carson, D.D. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  3. Relation of cholesterol-stimulated Staphylococcus aureus growth to chronic blepharitis. Shine, W.E., Silvany, R., McCulley, J.P. Invest. Ophthalmol. Vis. Sci. (1993) [Pubmed]
  4. The role of tetracycline in chronic blepharitis. Inhibition of lipase production in staphylococci. Dougherty, J.M., McCulley, J.P., Silvany, R.E., Meyer, D.R. Invest. Ophthalmol. Vis. Sci. (1991) [Pubmed]
  5. The efficacy of topical metronidazole in the treatment of ocular rosacea. Barnhorst, D.A., Foster, J.A., Chern, K.C., Meisler, D.M. Ophthalmology (1996) [Pubmed]
  6. Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo. Leib, D.A., Harrison, T.E., Laslo, K.M., Machalek, M.A., Moorman, N.J., Virgin, H.W. J. Exp. Med. (1999) [Pubmed]
  7. Periocular inflammation in mice with experimental systemic lupus erythematosus. A new experimental blepharitis and its modulation. Chan, C.C., Gery, I., Kohn, L.D., Nussenblatt, R.B., Mozes, E., Singer, D.S. J. Immunol. (1995) [Pubmed]
  8. Improved protection from primary ocular HSV-1 infection and establishment of latency using multigenic DNA vaccines. Osorio, Y., Cohen, J., Ghiasi, H. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  9. Enhanced secretory group II PLA2 activity in the tears of chronic blepharitis patients. Song, C.H., Choi, J.S., Kim, D.K., Kim, J.C. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  10. The role of wax and sterol ester fatty acids in chronic blepharitis. Dougherty, J.M., Osgood, J.K., McCulley, J.P. Invest. Ophthalmol. Vis. Sci. (1991) [Pubmed]
  11. The role of cholesterol in chronic blepharitis. Shine, W.E., McCulley, J.P. Invest. Ophthalmol. Vis. Sci. (1991) [Pubmed]
  12. Efficacy and safety of mercuric oxide in the treatment of bacterial blepharitis. Hyndiuk, R.A., Burd, E.M., Hartz, A. Antimicrob. Agents Chemother. (1990) [Pubmed]
  13. The ocular surface in cystic fibrosis. Sheppard, J.D., Orenstein, D.M., Chao, C.C., Butala, S., Kowalski, R.P. Ophthalmology (1989) [Pubmed]
  14. Oral pilocarpine for the treatment of ocular symptoms in patients with Sjögren's syndrome: a randomised 12 week controlled study. Tsifetaki, N., Kitsos, G., Paschides, C.A., Alamanos, Y., Eftaxias, V., Voulgari, P.V., Psilas, K., Drosos, A.A. Ann. Rheum. Dis. (2003) [Pubmed]
  15. N-acetylcysteine in chronic blepharitis. Yalçin, E., Altin, F., Cinhüseyinoglue, F., Arslan, M.O. Cornea (2002) [Pubmed]
  16. Minocycline effect on meibomian gland lipids in meibomianitis patients. Shine, W.E., McCulley, J.P., Pandya, A.G. Exp. Eye Res. (2003) [Pubmed]
  17. A rabbit model of staphylococcal blepharitis. Mondino, B.J., Caster, A.I., Dethlefs, B. Arch. Ophthalmol. (1987) [Pubmed]
  18. Ophthalmologic findings in the Cornelia de Lange Syndrome. Wygnanski-Jaffe, T., Shin, J., Perruzza, E., Abdolell, M., Jackson, L.G., Levin, A.V. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus. (2005) [Pubmed]
  19. Granulomatous blepharitis as a sign of Melkersson-Rosenthal syndrome. Yeatts, R.P., White, W.L. Ophthalmology (1997) [Pubmed]
  20. Clinical observations related to head lice infestation. Mumcuoglu, K.Y., Klaus, S., Kafka, D., Teiler, M., Miller, J. J. Am. Acad. Dermatol. (1991) [Pubmed]
  21. Retinol binding protein status in relation to ocular surface changes in patients with cystic fibrosis treated with daily vitamin A supplements. Mrugacz, M., Tobolczyk, J., Minarowska, A. Eur. J. Pediatr. (2005) [Pubmed]
  22. Blepharitis--a diagnostic and therapeutic challenge. A report on 407 consecutive cases. Huber-Spitzy, V., Baumgartner, I., Böhler-Sommeregger, K., Grabner, G. Graefes Arch. Clin. Exp. Ophthalmol. (1991) [Pubmed]
  23. Use of macrolides and tetracyclines for chronic inflammatory diseases. Voils, S.A., Evans, M.E., Lane, M.T., Schosser, R.H., Rapp, R.P. The Annals of pharmacotherapy. (2005) [Pubmed]
  24. Meibomianitis: polar lipid abnormalities. Shine, W.E., McCulley, J.P. Cornea (2004) [Pubmed]
  25. Clinical comparison of topical solutions containing trimethoprim in treating ocular surface bacterial infections. Foulks, G.N., Austin, R., Knowlton, G. Journal of ocular pharmacology. (1988) [Pubmed]
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