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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Efficacy of combined antidepressant therapy in resistant neurotic disorder.

A 35-year-old woman with persistent affective and phobic symptoms responded dramatically to a combination of isocarboxazid and amitriptyline, and this improvement was maintained over the next three-and-a-half years. Isocarboxazid was replaced by placebo, using double-blind procedure. The change to placebo was accompanied by a marked increase in anxiety and depressive symptoms, which resolved when active isocarboxazid was reintroduced. It is suggested that combined antidepressant therapy still has a place in the treatment of resistant neurotic disorder.[1]

References

  1. Efficacy of combined antidepressant therapy in resistant neurotic disorder. Tyrer, P., Murphy, S. The British journal of psychiatry : the journal of mental science. (1990) [Pubmed]
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