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Chemical Compound Review

isocarboxazid     N'-benzyl-5-methyl-1,2- oxazole-3...

Synonyms: Benazide, Maraplan, Enerzer, Marplan, Marplon, ...
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Disease relevance of isocarboxazid


Psychiatry related information on isocarboxazid


High impact information on isocarboxazid


Chemical compound and disease context of isocarboxazid


Biological context of isocarboxazid

  • The hydrolysis activity of eprinomectin and isocarboxazid, a specific substrate of RL2 [Hosokawa, M, Maki T and Satoh T (1987) Mol Pharmacol 31:579-584], by liver microsomes from rats treated with various cytochrome P-450 inducers correlated well (r = 0.92) [15].
  • In addition, in the strain EHBR, liver microsomal hydrolase activities of acetanilide and isocarboxazid which are hydrolyzed well by esterase-3 were lower than in outbred Sprague-Dawley rat and inbred LEW rat having the D phenotype of esterase-3 [16].

Associations of isocarboxazid with other chemical compounds


Gene context of isocarboxazid

  • Novel 2-alkylsulfanyl-1-benzyl-5-imidazolecarboxylic acid hydrazides (15a,b) were synthesized as analogues of isocarboxazide, which is a known nonselective irreversible monoamine oxidase inhibitor and tested for monoamine oxidase A and B inhibitory activity [22].
  • Also, elusion profiles of esterase by gel filtration and ion exchange chromatography demonstrated that the active protein(s) for eprinomectin and isocarboxazid hydrolysis coeluted [15].
  • The increase in holo/apo ratio of rat TP activity after addition of BZH in concentration of 1 x 10(-4)M, which is a major metabolite of isocarboxazid (ISOC), was higher than those in mice and guinea pigs [23].

Analytical, diagnostic and therapeutic context of isocarboxazid


  1. Case report of successful treatment of bulimia with isocarboxazid. Kronig, M.H. The American journal of psychiatry. (1986) [Pubmed]
  2. The importance of dose in isocarboxazid therapy. Davidson, J., Turnbull, C. The Journal of clinical psychiatry. (1984) [Pubmed]
  3. The effects of isocarboxazid on blood pressure and pulse. Davidson, J., Turnbull, C.D. Journal of clinical psychopharmacology. (1986) [Pubmed]
  4. Body weight changes associated with psychopharmacology. Vanina, Y., Podolskaya, A., Sedky, K., Shahab, H., Siddiqui, A., Munshi, F., Lippmann, S. Psychiatric services (Washington, D.C.) (2002) [Pubmed]
  5. The response of depressed inpatients to isocarboxazid. Davidson, J., Lipper, S., Pelton, S., Miller, R.D., Hammett, E.B., Mahorney, S., Varia, I.M. Journal of clinical psychopharmacology. (1988) [Pubmed]
  6. Monoamine oxidase inhibitor therapy for anorexia nervosa and bulimia: a preliminary trial of isocarboxazid. Kennedy, S.H., Piran, N., Garfinkel, P.E. Journal of clinical psychopharmacology. (1985) [Pubmed]
  7. Efficacy of combined antidepressant therapy in resistant neurotic disorder. Tyrer, P., Murphy, S. The British journal of psychiatry : the journal of mental science. (1990) [Pubmed]
  8. Mania induced by tricyclic-MAOI combination therapy in bipolar treatment-resistant disorder: case reports. de la Fuente, J.R., Berlanga, C., León-Andrade, C. The Journal of clinical psychiatry. (1986) [Pubmed]
  9. Action of antidepressants on the septal nuclei of the rat. Contreras, C.M., Alcalá-Herrera, V., Marván, M.L. Physiol. Behav. (1989) [Pubmed]
  10. Response to isocarboxazid and the DST. Davidson, J. The American journal of psychiatry. (1983) [Pubmed]
  11. MAOIs in the contemporary treatment of depression. Thase, M.E., Trivedi, M.H., Rush, A.J. Neuropsychopharmacology (1995) [Pubmed]
  12. Monoamine oxidase inhibitors in the treatment of atypical depression. Zisook, S., Braff, D.L., Click, M.A. Journal of clinical psychopharmacology. (1985) [Pubmed]
  13. The effect of the monoamine oxidase inhibitor isocarboxazid on the canine metabolism of the cell-differentiating agent hexamethylene bisacetamide. Conley, B.A., Sewack, G.F., Egorin, M.J., Subramanyam, B., Page, J.G., Grieshaber, C.K. Cancer Chemother. Pharmacol. (1991) [Pubmed]
  14. Behavioural teratology: post-natal consequences of drug exposure in utero. Leonard, B.E. Arch. Toxicol. Suppl. (1982) [Pubmed]
  15. Characterization of eprinomectin N-deacetylase in rats. Zeng, Z., Andrew, N.W. Drug Metab. Dispos. (1999) [Pubmed]
  16. Strain differences of rat liver carboxylesterase activities related to the phenotype difference of esterase-3 (egasyn). Nakamura, T., Satoh, T., Horie, T., Sagami, F., Tagaya, O. Res. Commun. Chem. Pathol. Pharmacol. (1989) [Pubmed]
  17. Failure of isocarboxazid and haloperidol to alleviate delusional depression in a pilot study. Davidson, J., Miller, R., Wingfield, M., Dougherty, G. Journal of clinical psychopharmacology. (1982) [Pubmed]
  18. Differential responses of rat hepatic microsomal carboxylesterase isozymes to glucocorticoids and pregnenolone 16 alpha-carbonitrile. Hosokawa, M., Hattori, K., Satoh, T. Biochem. Pharmacol. (1993) [Pubmed]
  19. Effect of benzodiazepines on central serotonergic neuron systems. Nakamura, M., Fukushima, H. Psychopharmacology (Berl.) (1977) [Pubmed]
  20. Species differences in the induction of hepatic microsomal carboxylesterases caused by dietary exposure to di(2-ethylhexyl)phthalate, a peroxisome proliferator. Hosokawa, M., Hirata, K., Nakata, F., Suga, T., Satoh, T. Drug Metab. Dispos. (1994) [Pubmed]
  21. Moclobemide in depression: a randomized, multicentre trial against isocarboxazide and clomipramine emphasizing atypical depression. Larsen, J.K., Gjerris, A., Holm, P., Anderson, J., Bille, A., Christensen, E.M., Høyer, E., Jensen, H., Mejlhede, A., Langagergaard, A. Acta psychiatrica Scandinavica. (1991) [Pubmed]
  22. Synthesis of novel N-substituted imidazolecarboxylic acid hydrazides as monoamine oxidase inhibitors. Hadizadeh, F., Ghodsi, R. Farmaco (2005) [Pubmed]
  23. Activation of tryptophan pyrrolase by benzylhydrazine. Satoh, T. Acta Vitaminol. Enzymol. (1975) [Pubmed]
  24. A trial of isocarboxazid in the treatment of bulimia nervosa. Kennedy, S.H., Piran, N., Warsh, J.J., Prendergast, P., Mainprize, E., Whynot, C., Garfinkel, P.E. Journal of clinical psychopharmacology. (1988) [Pubmed]
  25. Determination of marplan in human plasma using high-performance liquid chromatography. Powell, M.L., Town, C., Henderson, L., Buck, C. J. Chromatogr. (1990) [Pubmed]
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