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Functional sites on Ia molecules: a molecular dissection of A alpha immunogenicity.

Ia antigens are polymorphic cell-surface molecules that control the immune response. We have begun to localize important functional sites on one of the Ia molecules, A alpha. Herein, we focus on the A alpha k and A alpha b alleles and ask what defines "b-ness" and "k-ness" for a panel of monoclonal antibodies. Two independent experimental strategies are employed: the ability of 12 monoclonal antibodies to recognize L cell transfectants bearing chimeric and mutant A alpha chains is assessed, and the amino acid sequences of A alpha chains expressed by immunoselected B lymphoma mutants are deduced. For each antibody, we identify a stretch of polymorphic residues critical for recognition; for several, we can pinpoint a single amino acid. Certain stretches of A alpha (depending on the allele) appear strikingly immunodominant.[1]


  1. Functional sites on Ia molecules: a molecular dissection of A alpha immunogenicity. Landais, D., Waltzinger, C., Beck, B.N., Staub, A., McKean, D.J., Benoist, C., Mathis, D. Cell (1986) [Pubmed]
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