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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Dissection

  • Studies of events associated with primary HIV infection, examination of lymphoid tissue at various stages of disease, and dissection of the immunologic and virologic components of LTNP should contribute substantially to our understanding of the pathogenesis of HIV disease [1].
  • Functional dissection of the HIV-1 Rev trans-activator--derivation of a trans-dominant repressor of Rev function [2].
  • Disruption of elastin was believed to lead to dissection of arteries, but we showed that mutations in one allele encoding elastin cause a human disease in which arteries are blocked, namely, supravalvular aortic stenosis [3].
  • Our data show that haploinsufficiency of Tbx1 is sufficient to generate at least one important component of the DiGeorge syndrome phenotype in mice, and demonstrate the suitability of the mouse for the genetic dissection of microdeletion syndromes [4].
  • Finally, developing immunospecific forms of therapy for Graves' disease will require painstaking dissection of immune recognition and responses to the TSHR [5].

Psychiatry related information on Dissection


High impact information on Dissection

  • Dissection of the TCR utilizing chimeric receptors and TCR mutants has demonstrated that the multi-subunit receptor is composed of at least two signal transducing modules, the CD3 and the zeta chain subunits [11].
  • The dissection of the system has been greatly facilitated by discovery of the osteopetrotic op/op mouse, which has a spontaneous knockout of the gene for CSF-1 and possesses generalized but differential deficiency of various local subpopulations of M phi [12].
  • Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice [13].
  • These data localize the sterol-regulated step to budding of SCAP from ER and provide a system for biochemical dissection [14].
  • SUMMARY: Drosophila phototransduction is a G protein-coupled, calcium-regulated signaling cascade that serves as a model system for the dissection of phospholipase C (PLC) signaling in vivo [15].

Chemical compound and disease context of Dissection

  • Continuous propranolol infusion might also be useful in other clinical situations, such as acute aortic dissection or severe thyrotoxicosis, where predictable therapeutic serum propranolol levels could be maintained when oral therapy was contraindicated [16].
  • Information from studies with whole viruses, as well as protein dissection, has suggested that the fusion glycoprotein (F) from Paramyxoviridae, a family that includes major human pathogens, has two hydrophobic segments, termed fusion peptides [17].
  • In addition, four procedural factors were found to be associated with closure by univariate analysis: post-PTCA percent stenosis (p less than .001), intimal tear or dissection (p less than .001), use of prolonged heparin infusion (p less than .001), and post-PTCA gradient of 20 mm Hg or more (p = .004) [18].
  • Functional dissection of the transmitter module of the histidine kinase NtrB in Escherichia coli [19].
  • An additional 16 patients (0.8%) were given verapamil as part of the management of a flow-limiting dissection or distal embolus (mechanical obstruction) [20].

Biological context of Dissection


Anatomical context of Dissection


Associations of Dissection with chemical compounds


Gene context of Dissection

  • The ability to visualize repair intermediates in the absence of PCNA facilitates dissection of the multiprotein reaction that leads to incision of damaged DNA in a major pathway of cellular defense against mutagens [36].
  • Functional dissection and sequence of yeast HAP1 activator [22].
  • Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast [37].
  • Functional dissection of the yeast Cyc8-Tup1 transcriptional co-repressor complex [38].
  • Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses [39].

Analytical, diagnostic and therapeutic context of Dissection


  1. New concepts in the immunopathogenesis of HIV infection. Pantaleo, G., Fauci, A.S. Annu. Rev. Immunol. (1995) [Pubmed]
  2. Functional dissection of the HIV-1 Rev trans-activator--derivation of a trans-dominant repressor of Rev function. Malim, M.H., Böhnlein, S., Hauber, J., Cullen, B.R. Cell (1989) [Pubmed]
  3. Elastin is an essential determinant of arterial morphogenesis. Li, D.Y., Brooke, B., Davis, E.C., Mecham, R.P., Sorensen, L.K., Boak, B.B., Eichwald, E., Keating, M.T. Nature (1998) [Pubmed]
  4. Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice. Lindsay, E.A., Vitelli, F., Su, H., Morishima, M., Huynh, T., Pramparo, T., Jurecic, V., Ogunrinu, G., Sutherland, H.F., Scambler, P.J., Bradley, A., Baldini, A. Nature (2001) [Pubmed]
  5. Insight into Graves' hyperthyroidism from animal models. McLachlan, S.M., Nagayama, Y., Rapoport, B. Endocr. Rev. (2005) [Pubmed]
  6. Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau. Hardy, J., Duff, K., Hardy, K.G., Perez-Tur, J., Hutton, M. Nat. Neurosci. (1998) [Pubmed]
  7. Panic disorder subtypes: differential responses to CO2 challenge. Biber, B., Alkin, T. The American journal of psychiatry. (1999) [Pubmed]
  8. Melanin-concentrating hormone is a potent anorectic peptide regulated by food-deprivation and glucopenia in the rat. Presse, F., Sorokovsky, I., Max, J.P., Nicolaidis, S., Nahon, J.L. Neuroscience (1996) [Pubmed]
  9. Use of selective serotonin reuptake inhibitors and other serotonergic drugs in the biological dissection of affective disorders. Nutt, D.J., Wilson, S.J., Coupland, N.J. International clinical psychopharmacology. (1995) [Pubmed]
  10. Biological dissection of anxiety disorders: the clinical role of selective serotonin reuptake inhibitors with particular reference to fluvoxamine. den Boer, J.A., Westenberg, H.G., De Leeuw, A.S., van Vliet, I.M. International clinical psychopharmacology. (1995) [Pubmed]
  11. The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. Chan, A.C., Desai, D.M., Weiss, A. Annu. Rev. Immunol. (1994) [Pubmed]
  12. Cytokine regulation of the macrophage (M phi) system studied using the colony stimulating factor-1-deficient op/op mouse. Wiktor-Jedrzejczak, W., Gordon, S. Physiol. Rev. (1996) [Pubmed]
  13. Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Yalcin, B., Willis-Owen, S.A., Fullerton, J., Meesaq, A., Deacon, R.M., Rawlins, J.N., Copley, R.R., Morris, A.P., Flint, J., Mott, R. Nat. Genet. (2004) [Pubmed]
  14. Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes. Nohturfft, A., Yabe, D., Goldstein, J.L., Brown, M.S., Espenshade, P.J. Cell (2000) [Pubmed]
  15. The Drosophila light-activated conductance is composed of the two channels TRP and TRPL. Niemeyer, B.A., Suzuki, E., Scott, K., Jalink, K., Zuker, C.S. Cell (1996) [Pubmed]
  16. Continuous propranolol infusion following abdominal surgery. Smulyan, H., Weinberg, S.E., Howanitz, P.J. JAMA (1982) [Pubmed]
  17. New insights into the mechanism of virus-induced membrane fusion. Peisajovich, S.G., Shai, Y. Trends Biochem. Sci. (2002) [Pubmed]
  18. Angiographic and clinical predictors of acute closure after native vessel coronary angioplasty. Ellis, S.G., Roubin, G.S., King, S.B., Douglas, J.S., Weintraub, W.S., Thomas, R.G., Cox, W.R. Circulation (1988) [Pubmed]
  19. Functional dissection of the transmitter module of the histidine kinase NtrB in Escherichia coli. Kramer, G., Weiss, V. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  20. Incidence and treatment of 'no-reflow' after percutaneous coronary intervention. Piana, R.N., Paik, G.Y., Moscucci, M., Cohen, D.J., Gibson, C.M., Kugelmass, A.D., Carrozza, J.P., Kuntz, R.E., Baim, D.S. Circulation (1994) [Pubmed]
  21. Molecular genetic dissection of myosin heavy chain function. Kiehart, D.P. Cell (1990) [Pubmed]
  22. Functional dissection and sequence of yeast HAP1 activator. Pfeifer, K., Kim, K.S., Kogan, S., Guarente, L. Cell (1989) [Pubmed]
  23. Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice. Guy, C.T., Muthuswamy, S.K., Cardiff, R.D., Soriano, P., Muller, W.J. Genes Dev. (1994) [Pubmed]
  24. Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. Xu, X., Yin, Z., Hudson, J.B., Ferguson, E.L., Frasch, M. Genes Dev. (1998) [Pubmed]
  25. Ribonuclease E provides substrates for ribonuclease P-dependent processing of a polycistronic mRNA. Alifano, P., Rivellini, F., Piscitelli, C., Arraiano, C.M., Bruni, C.B., Carlomagno, M.S. Genes Dev. (1994) [Pubmed]
  26. Cocaine-induced coronary-artery dissection. Jaffe, B.D., Broderick, T.M., Leier, C.V. N. Engl. J. Med. (1994) [Pubmed]
  27. Atomic force microscopy and dissection of gap junctions. Hoh, J.H., Lal, R., John, S.A., Revel, J.P., Arnsdorf, M.F. Science (1991) [Pubmed]
  28. Genetic dissection of Drosophila myofibril formation: effects of actin and myosin heavy chain null alleles. Beall, C.J., Sepanski, M.A., Fyrberg, E.A. Genes Dev. (1989) [Pubmed]
  29. T cell hybrids with arsonate specificity. I. Initial characterization of antigen-specific T cell products that bear a cross-reactive idiotype and determinants encoded by the murine major histocompatibility complex. Pacifico, A., Capra, J.D. J. Exp. Med. (1980) [Pubmed]
  30. NCAM and vesicle cycling: the importance of good glue in the long run. Ryan, T.A. Neuron (2001) [Pubmed]
  31. Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases. Rogge, R.D., Karlovich, C.A., Banerjee, U. Cell (1991) [Pubmed]
  32. Functional sites on Ia molecules: a molecular dissection of A alpha immunogenicity. Landais, D., Waltzinger, C., Beck, B.N., Staub, A., McKean, D.J., Benoist, C., Mathis, D. Cell (1986) [Pubmed]
  33. Intravenous labetalol in acute aortic dissection. Grubb, B.P., Sirio, C., Zelis, R. JAMA (1987) [Pubmed]
  34. Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of determinants of alpha-conotoxin M1 selectivity. Sine, S.M., Kreienkamp, H.J., Bren, N., Maeda, R., Taylor, P. Neuron (1995) [Pubmed]
  35. A molecular dissection of the glycoprotein hormone receptors. Vassart, G., Pardo, L., Costagliola, S. Trends Biochem. Sci. (2004) [Pubmed]
  36. Proliferating cell nuclear antigen is required for DNA excision repair. Shivji, K.K., Kenny, M.K., Wood, R.D. Cell (1992) [Pubmed]
  37. Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast. Hope, I.A., Struhl, K. Cell (1986) [Pubmed]
  38. Functional dissection of the yeast Cyc8-Tup1 transcriptional co-repressor complex. Tzamarias, D., Struhl, K. Nature (1994) [Pubmed]
  39. Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Ohtani, T., Ishihara, K., Atsumi, T., Nishida, K., Kaneko, Y., Miyata, T., Itoh, S., Narimatsu, M., Maeda, H., Fukada, T., Itoh, M., Okano, H., Hibi, M., Hirano, T. Immunity (2000) [Pubmed]
  40. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Hornung, V., Guenthner-Biller, M., Bourquin, C., Ablasser, A., Schlee, M., Uematsu, S., Noronha, A., Manoharan, M., Akira, S., de Fougerolles, A., Endres, S., Hartmann, G. Nat. Med. (2005) [Pubmed]
  41. Intracoronary stenting and risk for major adverse cardiac events during the first month. Schühlen, H., Kastrati, A., Dirschinger, J., Hausleiter, J., Elezi, S., Wehinger, A., Pache, J., Hadamitzky, M., Schömig, A. Circulation (1998) [Pubmed]
  42. Circulatory management with retrograde cerebral perfusion for acute type A aortic dissection. Bavaria, J.E., Woo, Y.J., Hall, R.A., Wahl, P.M., Acker, M.A., Gardner, T.J. Circulation (1996) [Pubmed]
  43. Laser balloon angioplasty. A new approach to abrupt coronary occlusion and chronic restenosis. Jenkins, R.D., Spears, J.R. Circulation (1990) [Pubmed]
  44. Relation of coronary angioscopic findings at coronary angioplasty to angiographic restenosis. Bauters, C., Lablanche, J.M., McFadden, E.P., Hamon, M., Bertrand, M.E. Circulation (1995) [Pubmed]
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