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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Action of 3-methylquercetin on poliovirus RNA replication.

3-Methylquercetin is a natural flavone that powerfully blocks poliovirus replication. This compound inhibits selectively poliovirus RNA synthesis both in infected cells and in cell-free systems. Poliovirus double-stranded RNA (replicative forms) is still made in the presence of this inhibitor, whereas the synthesis of single-stranded RNA and the formation of replicative intermediates are drastically blocked.[1]


  1. Action of 3-methylquercetin on poliovirus RNA replication. Castrillo, J.L., Carrasco, L. J. Virol. (1987) [Pubmed]
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