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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effect of trimebutine maleate on sinus node pacemaker activity of the rabbit.

The electrophysiological effects of trimebutine maleate were studied on rabbit sinus node cells with the two-microelectrode voltage clamp method. Trimebutine (above 10 microM) produced a negative chronotropic effect accompanied by decreases in the maximum upstroke velocity at phase 0, slope of phase 4 depolarization and action potential amplitude. The effects on the current systems were depression of the slow inward current and a decrease in the current oscillations induced by elevating [Ca]0. It is concluded that trimebutine exerts a Ca2+ channel blocking effect on the sinus node pacemaker cells.[1]

References

  1. Effect of trimebutine maleate on sinus node pacemaker activity of the rabbit. Kotake, H., Kinugawa, T., Hirai, S., Fukugi, M., Hasegawa, J., Mashiba, H. Eur. J. Pharmacol. (1987) [Pubmed]
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