The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Debridat     (2-dimethylamino-2-phenyl- butyl) 3,4,5...

Synonyms: Trimedat, Trimebutino, trimebutine, Trimebutinum, SureCN25705, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of trimebutine


Psychiatry related information on trimebutine

  • The effects of trimebutine and domperidone, on the electrical and motor activity of the upper small bowel in dogs, were studied simultaneously by means of a suction electrode and a manometric catheter [6].

High impact information on trimebutine


Chemical compound and disease context of trimebutine


Biological context of trimebutine


Anatomical context of trimebutine


Associations of trimebutine with other chemical compounds


Gene context of trimebutine


Analytical, diagnostic and therapeutic context of trimebutine


  1. Duodenogastric reflux following cholecystectomy in the dog: role of antroduodenal motor function. Nogi, K., Haruma, K., Taniguchi, H., Yomota, E., Okajima, M., Hananoki, M., Hata, J., Kusunoki, H., Onoda, Y. Aliment. Pharmacol. Ther. (2001) [Pubmed]
  2. Rizatriptan vs. rizatriptan plus trimebutine for the acute treatment of migraine: a double-blind, randomized, cross-over, placebo-controlled study. Krymchantowski, A.V., Filho, P.F., Bigal, M.E. Cephalalgia : an international journal of headache. (2006) [Pubmed]
  3. Effects of trimebutine on colonic function in patients with chronic idiopathic constipation: evidence for the need of a physiologic rather than clinical selection. Schang, J.C., Devroede, G., Pilote, M. Dis. Colon Rectum (1993) [Pubmed]
  4. Delayed reaction urticaria due to trimebutine. Martin-Garcia, C., Martinez-Borque, N., Martinez-Bohigas, D., Torrecillas-Toro, M., Palomeque-Rodrìguez, M.T. Allergy (2004) [Pubmed]
  5. A three-part controlled study of trimebutine in the treatment of irritable colon syndrome. Lüttecke, K. Current medical research and opinion. (1980) [Pubmed]
  6. Short report: effect of two prokinetic drugs on the electrical and motor activity of the small bowel in dogs. Defilippi, C., Gomez, E. Aliment. Pharmacol. Ther. (1993) [Pubmed]
  7. Rectal instillation of butyrate provides a novel clinically relevant model of noninflammatory colonic hypersensitivity in rats. Bourdu, S., Dapoigny, M., Chapuy, E., Artigue, F., Vasson, M.P., Dechelotte, P., Bommelaer, G., Eschalier, A., Ardid, D. Gastroenterology (2005) [Pubmed]
  8. Dual effect of trimebutine on contractility of the guinea pig ileum via the opioid receptors. Taniyama, K., Sano, I., Nakayama, S., Matsuyama, S., Takeda, K., Yoshihara, C., Tanaka, C. Gastroenterology (1991) [Pubmed]
  9. Influence of trimebutine on inflammation- and stress-induced hyperalgesia to rectal distension in rats. Lacheze, C., Coelho, A.M., Fioramonti, J., Buéno, L. J. Pharm. Pharmacol. (1998) [Pubmed]
  10. Synthesis of methylamino-2-phenyl-2-butyl-3,4,5-trimethoxybenzoate, the main bioactive metabolite of trimebutine maleate. Martin, A., Figadère, B., Saivin, S., Houin, G., Chomard, J.M., Cahiez, G. Arzneimittel-Forschung. (2000) [Pubmed]
  11. Effects of TAK-637, a novel neurokinin-1 receptor antagonist, on colonic function in vivo. Okano, S., Nagaya, H., Ikeura, Y., Natsugari, H., Inatomi, N. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  12. Peripheral antagonistic action of trimebutine and kappa opioid substances on acoustic stress-induced gastric motor inhibition in dogs. Gué, M., Pascaud, X., Hondé, C., Junien, J.L., Buéno, L. Eur. J. Pharmacol. (1988) [Pubmed]
  13. Trimebutine-induced phase III-like activity in infants with intestinal motility disorders. Boige, N., Cargill, G., Mashako, L., Cezard, J.P., Navarro, J. J. Pediatr. Gastroenterol. Nutr. (1987) [Pubmed]
  14. Motility of the Roux-en-Y hepaticojejunostomy in asymptomatic patients. Le Blanc-Louvry, I., Ducrotté, P., Manouvrier, J.L., Peillon, C., Testart, J., Denis, P. Am. J. Gastroenterol. (1999) [Pubmed]
  15. Local actions of trimebutine maleate in canine small intestine. Daniel, E.E., Kostolanska, F., Allescher, H.D., Ahmad, S., Fox, J.E. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  16. Effects of trimebutine on sphincter of Oddi motility in patients with post-cholecystectomy pain. Barthet, M., Bouvier, M., Pecout, C., Berdah, S., Viviand, X., Mambrini, P., Abou, E., Salducci, J., Grimaud, J.C. Aliment. Pharmacol. Ther. (1998) [Pubmed]
  17. Rotenone and oligomycin-like action of trimebutine on liver mitochondria. Siliprandi, D., Toninello, A., Gobbato, S. Biochem. Pharmacol. (1979) [Pubmed]
  18. Randomized controlled trial of trimebutine (anal sphincter relaxant) for pain after haemorrhoidectomy. Ho, Y.H., Seow-Choen, F., Low, J.Y., Tan, M., Leong, A.P. The British journal of surgery. (1997) [Pubmed]
  19. Interaction of trimebutine and Jo-1196 (fedotozine) with opioid receptors in the canine ileum. Allescher, H.D., Ahmad, S., Classen, M., Daniel, E.E. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  20. Effects of spasmolytics on K+-induced contraction of rat intestine in vivo. Subissi, A., Brunori, P., Bachi, M. Eur. J. Pharmacol. (1983) [Pubmed]
  21. Fenoverine: smooth muscle synchronizer for the management of gastro-intestinal conditions. II. A trimebutine-controlled, double-blind, crossover clinical evaluation. Camarri, E. Current medical research and opinion. (1986) [Pubmed]
  22. Effect of trimebutine on contractile responses in skinned ileal smooth muscle. Nagasaki, M., Itagaki, M., Komori, S., Ohashi, H. Jpn. J. Pharmacol. (1994) [Pubmed]
  23. Effect of trimebutine maleate on emptying of stomach and gallbladder and release of gut peptide following a solid meal in man. Okano, H., Saeki, S., Inui, A., Kawai, Y., Ohno, S., Morimoto, S., Ohmoto, A., Nakashima, T., Miyamoto, M., Okita, M. Dig. Dis. Sci. (1993) [Pubmed]
  24. Comparison of the effects of trimebutine and YM114 (KAE-393), a novel 5-HT3 receptor antagonist, on stress-induced defecation. Miyata, K., Ito, H., Yamano, M., Hidaka, K., Kamato, T., Nishida, A., Yuki, H. Eur. J. Pharmacol. (1993) [Pubmed]
  25. The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies. Kaneto, H., Takahashi, M., Watanabe, J. J. Pharmacobio-dyn. (1990) [Pubmed]
  26. Effect of trimebutine on intestinal motility and plasma motilin in the dog. Poitras, P., Honde, C., Havrankova, J., Lahaie, R.G., Trudel, L., Goyer, R., Junien, J.L., Pascaud, X. Am. J. Physiol. (1986) [Pubmed]
  27. A comparison of metoclopramide and trimebutine on small bowel motility in humans. Grandjouan, S., Chaussade, S., Couturier, D., Thierman-Duffaud, D., Henry, J.F. Aliment. Pharmacol. Ther. (1989) [Pubmed]
  28. Effect of trimebutine on voltage-activated calcium current in rabbit ileal smooth muscle cells. Nagasaki, M., Komori, S., Ohashi, H. Br. J. Pharmacol. (1993) [Pubmed]
WikiGenes - Universities