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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Human beta 2-microglobulin specifically enhances cell-surface expression of HLA class I molecules in transfected murine cells.

Sequential transfections of P815 murine mastocytoma cells with class I gene encoding either HLA-Cw3, HLA-A3, or HLA-B7 H chain and subsequently with a human beta 2-microglobulin gene were performed to evaluate the relative efficiency of human and murine beta 2-microglobulins in promoting the cell-surface expression of HLA-class I molecules. A 6-, 11-, and 40-fold specific enhancement of the cell-surface expression of HLA-Cw3, HLA-A3, and HLA-B7 molecules, respectively, was observed in cells co-transfected with human beta 2-microglobulin gene. This effect was attributed to a more efficient association of HLA H chains with human than with murine beta 2-microglobulin, which apparently allowed a more rapid transport of the HLA molecules from the endoplasmic reticulum to the Golgi apparatus.[1]

References

  1. Human beta 2-microglobulin specifically enhances cell-surface expression of HLA class I molecules in transfected murine cells. Perarnau, B.M., Gillet, A.C., Hakem, R., Barad, M., Lemonnier, F.A. J. Immunol. (1988) [Pubmed]
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