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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A randomized trial of the use of cocaine spray to provide pain relief during laser vaporization of the cervix.

In a double-blind trial, 50 patients undergoing laser vaporization of the cervix for cervical intraepithelial neoplasia were randomly allocated to one of two groups. One group had the cervix sprayed with 3-4 ml of a solution containing 10% cocaine, the other a placebo solution during the laser treatment. Women in the cocaine group had significantly less pain as assessed by a visual analogue scale (P less than 0.001) and by a verbal rating scale (P = 0.002). The cocaine group also had less blood loss (P = 0.001) as assessed subjectively by the operator.[1]

References

  1. A randomized trial of the use of cocaine spray to provide pain relief during laser vaporization of the cervix. Mikhail, M.G., Bevan, J.R. British journal of obstetrics and gynaecology. (1988) [Pubmed]
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