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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Thromboxane A2 receptor antagonists. II. Synthesis and pharmacological activity of 6,6-dimethylbicyclo[3.1.1]heptane derivatives with the benzenesulfonylamino group.

Various stereoisomers based on the alpha- and omega-side chain ring junctions of 6,6-dimethylbicyclo[3.1.1]heptane were synthesized. Their sodium salts 12, 18, 20, 30 and 37 were examined in vitro for their inhibitory activity toward aggregation of rabbit platelet-rich plasma and rat washed platelets. Their potency was very high and the partial agonist effect was small. The differences of the side chain ring junctions did not affect the activity very much. Homologation in the omega-side chain (as in 47) decreased the activity.[1]

References

  1. Thromboxane A2 receptor antagonists. II. Synthesis and pharmacological activity of 6,6-dimethylbicyclo[3.1.1]heptane derivatives with the benzenesulfonylamino group. Seno, K., Hagishita, S. Chem. Pharm. Bull. (1989) [Pubmed]
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