The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Tbxa2r  -  thromboxane A2 receptor

Rattus norvegicus

Synonyms: Prostanoid TP receptor, TXA2-R, TXR2, Thromboxane A2 receptor
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tbxa2r


High impact information on Tbxa2r


Chemical compound and disease context of Tbxa2r


Biological context of Tbxa2r


Anatomical context of Tbxa2r


Associations of Tbxa2r with chemical compounds


Regulatory relationships of Tbxa2r

  • This stimulation is specifically mediated by TxA2 (thromboxane prostanoid, TP) receptors, since U-46619 also stimulates PAI-1 expression in cells that are transfected with TP receptors, and this stimulation of PAI-1 production is completely blocked by the TxA2 receptor antagonist, SQ-29,548 [30].

Other interactions of Tbxa2r


Analytical, diagnostic and therapeutic context of Tbxa2r


  1. Role of thromboxane A2, endothelin-1 and endothelin-3 in rat nephrotoxic serum nephritis. Zhou, L., Ida, T., Marumo, F. Tohoku J. Exp. Med. (1996) [Pubmed]
  2. Effects of thromboxane A2 receptor blockade on oliguric ischemic acute renal failure in conscious rats. Kramer, H.J., Mohaupt, M.G., Pinoli, F., Bäcker, A., Meyer-Lehnert, H., Schlebusch, H. J. Am. Soc. Nephrol. (1993) [Pubmed]
  3. Thromboxane synthesis inhibition increases renal prostacyclin and prevents renal disease progression in rats with remnant kidney. Zoja, C., Perico, N., Corna, D., Benigni, A., Gabanelli, M., Morigi, M., Bertani, T., Remuzzi, G. J. Am. Soc. Nephrol. (1990) [Pubmed]
  4. Evaluation of the combination of a tissue-type plasminogen activator, SUN9216, and a thromboxane A2 receptor antagonist, vapiprost, in a rat middle cerebral artery thrombosis model. Umemura, K., Wada, K., Uematsu, T., Nakashima, M. Stroke (1993) [Pubmed]
  5. Effect of a novel thromboxane A2 receptor antagonist, S-1452, on postischemic brain injury in rats. Matsuo, Y., Izumiyama, M., Onodera, H., Kurosawa, A., Kogure, K. Stroke (1993) [Pubmed]
  6. Thromboxane A2 receptor blocking abrogates donor-specific unresponsiveness to renal allografts induced by thymic recognition of major histocompatibility allopeptides. Remuzzi, G., Noris, M., Benigni, A., Imberti, O., Sayegh, M.H., Perico, N. J. Exp. Med. (1994) [Pubmed]
  7. Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder. Hirata, T., Kakizuka, A., Ushikubi, F., Fuse, I., Okuma, M., Narumiya, S. J. Clin. Invest. (1994) [Pubmed]
  8. Glomerular actions of a free radical-generated novel prostaglandin, 8-epi-prostaglandin F2 alpha, in the rat. Evidence for interaction with thromboxane A2 receptors. Takahashi, K., Nammour, T.M., Fukunaga, M., Ebert, J., Morrow, J.D., Roberts, L.J., Hoover, R.L., Badr, K.F. J. Clin. Invest. (1992) [Pubmed]
  9. Renal vasoconstriction caused by short-term cholesterol feeding is corrected by thromboxane antagonist or probucol. Kaplan, R., Aynedjian, H.S., Schlondorff, D., Bank, N. J. Clin. Invest. (1990) [Pubmed]
  10. Leukotriene D4 participates in colonic transit disturbances induced by intracolonic administration of trinitrobenzene sulfonic acid in rats. Pons, L., Droy-Lefaix, M.T., Bueno, L. Gastroenterology (1992) [Pubmed]
  11. Prevention of thromboxane A2 receptor-mediated pulmonary hypertension by a nonpeptide angiotensin II type 1 receptor antagonist. Bertolino, F., Valentin, J.P., Maffre, M., Jover, B., Bessac, A.M., John, G.W. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  12. Antithrombotic effect of a novel recombinant hirudin analogue, CX-397, in a rat arterial thrombosis model. Takiguchi, Y., Asai, F., Wada, K., Hayashi, H., Nakashima, M. Br. J. Pharmacol. (1995) [Pubmed]
  13. The influence of hyperthyroidism on pharmacologically induced contractions of isolated resistance arteries. Zwaveling, J., Prins, E.A., Maas, M.A., Pfaffendorf, M., Van Zwieten, P.A. Eur. J. Pharmacol. (1996) [Pubmed]
  14. Cardiac-derived thromboxane A2. An initiating mediator of reperfusion injury? Byrne, J.G., Appleyard, R.F., Sun, S.C., Couper, G.S., Sloane, J.A., Laurence, R.G., Cohn, L.H. J. Thorac. Cardiovasc. Surg. (1993) [Pubmed]
  15. The effect of tumor necrosis factor-alpha on microvascular permeability in an isolated, perfused lung. Schulman, C.I., Wright, J.K., Nwariaku, F., Sarosi, G., Turnage, R.H. Shock (2002) [Pubmed]
  16. Assignment of the gene for rat thromboxane receptor (Tbxa2r) to chromosome 7q11 by fluorescence in situ hybridization. Takeuchi, K., Nakagawara, K., Mori, M., Abe, T., Takahashi, N., Tsutsumi, E., Taniyama, Y., Kato, T., Takeuchi, T., Abe, K. Cytogenet. Cell Genet. (1996) [Pubmed]
  17. Blood pressure and vascular effects of endothelin blockade in chronic nitric oxide-deficient hypertension. Moreau, P., Takase, H., Küng, C.F., Shaw, S., Lüscher, T.F. Hypertension (1997) [Pubmed]
  18. Peroxynitrite inhibits relaxation and induces pulmonary artery muscle contraction in the newborn rat. Belik, J., Jankov, R.P., Pan, J., Tanswell, A.K. Free Radic. Biol. Med. (2004) [Pubmed]
  19. Human bronchial smooth muscle cell proliferation via thromboxane A2 receptor. Suzuki, Y., Asano, K., Shiraishi, Y., Oguma, T., Shiomi, T., Fukunaga, K., Nakajima, T., Niimi, K., Yamaguchi, K., Ishizaka, A. Prostaglandins Leukot. Essent. Fatty Acids (2004) [Pubmed]
  20. Dissociation of the contractile and hypertrophic effects of vasoconstrictor prostanoids in vascular smooth muscle. Dorn, G.W., Becker, M.W., Davis, M.G. J. Biol. Chem. (1992) [Pubmed]
  21. cDNA cloning of a thromboxane A2 receptor from rat astrocytes. Kitanaka, J., Hashimoto, H., Sugimoto, Y., Sawada, M., Negishi, M., Suzumura, A., Marunouchi, T., Ichikawa, A., Baba, A. Biochim. Biophys. Acta (1995) [Pubmed]
  22. Identification of the thromboxane A2 receptor in hepatic sinusoidal endothelial cells and its role in endotoxin-induced liver injury in rats. Ishiguro, S., Arii, S., Monden, K., Adachi, Y., Funaki, N., Higashitsuji, H., Fujita, S., Furutani, M., Mise, M., Kitao, T. Hepatology (1994) [Pubmed]
  23. A role for uric acid in the progression of renal disease. Kang, D.H., Nakagawa, T., Feng, L., Watanabe, S., Han, L., Mazzali, M., Truong, L., Harris, R., Johnson, R.J. J. Am. Soc. Nephrol. (2002) [Pubmed]
  24. Mesangial cell immune injury: effects of thromboxane receptor antagonism. Bresnahan, B.A., Roman, R.J., Bagchus, W.M., Lianos, E.A. J. Am. Soc. Nephrol. (1991) [Pubmed]
  25. Effect of endothelin antagonists on the responses to prostanoid endothelium-derived contracting factor. Moreau, P., Takase, H., Lüscher, T.F. Br. J. Pharmacol. (1996) [Pubmed]
  26. Thromboxane A2 from Kupffer cells contributes to the hyperresponsiveness of hepatic portal circulation to endothelin-1 in endotoxemic rats. Xu, H., Korneszczuk, K., Karaa, A., Lin, T., Clemens, M.G., Zhang, J.X. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  27. BMS-180560, an insurmountable inhibitor of angiotensin II-stimulated responses: comparison with losartan and EXP3174. Dickinson, K.E., Cohen, R.B., Skwish, S., Delaney, C.L., Serafino, R.P., Poss, M.A., Gu, Z., Ryono, D.E., Moreland, S., Powell, J.R. Br. J. Pharmacol. (1994) [Pubmed]
  28. Cinnamophilin, a novel thromboxane A2 receptor antagonist, isolated from Cinnamomum philippinense. Yu, S.M., Ko, F.N., Wu, T.S., Lee, J.Y., Teng, C.M. Eur. J. Pharmacol. (1994) [Pubmed]
  29. Vascular responses to endothelin-1, angiotensin-II, and U46619 in glycerol-induced acute renal failure. Newaz, M.A., Oyekan, A.O. J. Cardiovasc. Pharmacol. (2001) [Pubmed]
  30. Thromboxane A2 modulates the fibrinolytic system in glomerular mesangial cells. Coffman, T.M., Spurney, R.F., Mannon, R.B., Levenson, R. Am. J. Physiol. (1998) [Pubmed]
  31. Effects of ANG II, ETA, and TxA2 receptor antagonists on cyclosporin A renal vasoconstriction. Conger, J.D., Kim, G.E., Robinette, J.B. Am. J. Physiol. (1994) [Pubmed]
  32. Regulatory role of eicosanoids in extracellular matrix overproduction induced by long-term exposure to high glucose in cultured rat mesangial cells. Pricci, F., Pugliese, G., Menè, P., Romeo, G., Romano, G., Galli, G., Casini, A., Rotella, C.M., DiMario, U., Pugliese, F. Diabetologia (1996) [Pubmed]
  33. Selective impairment of endothelium-dependent relaxations by prostaglandin endoperoxide. Tesfamariam, B. J. Hypertens. (1994) [Pubmed]
  34. Platelets protect against myocardial dysfunction and injury induced by ischemia and reperfusion in isolated rat hearts. Yang, B.C., Virmani, R., Nichols, W.W., Mehta, J.L. Circ. Res. (1993) [Pubmed]
  35. Involvement of thromboxane A2-thromboxane A2 receptor system of the hepatic sinusoid in pathogenesis of cold preservation/reperfusion injury in the rat liver graft. Ishiguro, S., Arii, S., Monden, K., Fujita, S., Nakamura, T., Niwano, M., Harada, T., Ushikubi, F., Narumiya, S., Imamura, M. Transplantation (1995) [Pubmed]
  36. FTIR spectral study of intramolecular hydrogen bonding in thromboxane A2 receptor antagonist S-145 and related compounds. 3. Conformation and activity of S-145 analogues. Takasuka, M., Yamakawa, M., Ohtani, M. J. Med. Chem. (1991) [Pubmed]
  37. Role of thromboxane A2 in muscle injury following ischaemia. Homer-Vanniasinkam, S., Crinnion, J.N., Gough, M.J. The British journal of surgery. (1994) [Pubmed]
WikiGenes - Universities