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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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UK-69,578, a novel inhibitor of EC 3.4.24.11 which increases endogenous ANF levels and is natriuretic and diuretic.

A search for potent inhibitors of EC 3.4.24.11, an enzyme which is found most abundantly in the kidney and which degrades atrial natriuretic factor, has led to the identification of UK-69,578. Structure-activity studies starting from substituted N-carboxymethyl dipeptide inhibitors resulted in the introduction of a cyclo-alkane P1' residue and in the replacement of the aza-link between P1 and P1' residues by a methylene group, with a net ten-fold potency gain. UK-69,578 increases endogenous ANF levels and produces natriuretic and diuretic responses intravenously in mice.[1]

References

  1. UK-69,578, a novel inhibitor of EC 3.4.24.11 which increases endogenous ANF levels and is natriuretic and diuretic. Danilewicz, J.C., Barclay, P.L., Barnish, I.T., Brown, D., Campbell, S.F., James, K., Samuels, G.M., Terrett, N.K., Wythes, M.J. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
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