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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Assay method for single-chain urokinase-type plasminogen activator.

A new assay method for measuring single-chain urokinase-type plasminogen activator (scu-PA) activity by quantitative calorimetric assay method is described. The serine enzyme u-PA activates plasminogen to plasmin, and scu-PA is a precursor protein obtained from a tissue culture of human kidney cells. The scu-PA solution was activated by plasmin to two-chain u-PA, which releases p-nitroaniline from pyro-Glu-Gly-Arg-pNA, and the optical density at 405 nm was measured. One unit of scu-PA was defined on the basis of 1 nmol of p-nitroaniline released from the substrate per second. One unit of scu-PA was found to be equivalent to 335 u-PA (two-chain) units (IU).[1]


  1. Assay method for single-chain urokinase-type plasminogen activator. Matsuo, O., Ueshima, S., Okada, K., Fukao, H., Ohgaki, M., Watanabe, R., Arimura, H. Hematologic pathology. (1989) [Pubmed]
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