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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Ischemic flow threshold for extracellular glutamate increase in cat cortex.

Extracellular glutamate (Glu), cerebral blood flow (CBF), and auditory-evoked potentials (AEPs) were measured concurrently using microdialysis and hydrogen clearance in the auditory cortex of anesthetized cats during global ischemia of various severities. A threshold-type relationship was observed between extracellular Glu and CBF: Glu increased at CBF levels below about 20 ml/100 g/min. The Glu increase was related to the impairment of AEPs. The results suggest that Glu neurotoxicity is an important factor for ischemic neuronal injury even in penumbra.[1]


  1. Ischemic flow threshold for extracellular glutamate increase in cat cortex. Shimada, N., Graf, R., Rosner, G., Wakayama, A., George, C.P., Heiss, W.D. J. Cereb. Blood Flow Metab. (1989) [Pubmed]
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