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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Microdialysis


Psychiatry related information on Microdialysis


High impact information on Microdialysis


Chemical compound and disease context of Microdialysis


Biological context of Microdialysis


Anatomical context of Microdialysis

  • The present study investigated the effect in freely moving rats of intravenous cocaine, amphetamine, and morphine on extracellular dopamine concentrations in the nucleus accumbens shell and core by means of microdialysis with vertically implanted concentric probes [26].
  • In line with LTP shortening, in vivo microdialysis showed a significant decrease in basal and K(+)-evoked extracellular glutamate levels in the hippocampus of juvenile and adult rats born from WIN-treated dams [27].
  • Exposure to the cocaine SDelta significantly increased dopamine efflux in the NAcc and amygdala as measured by intracranial microdialysis in a separate group of rats [28].
  • METHODS AND RESULTS: Skeletal muscle interstitial adenosine concentrations were determined by the microdialysis technique, in which 4 semipermeable microdialysis probes were inserted into the vastus lateralis muscle of 6 healthy male subjects and perfused at a rate of 5 microL/min with Ringer's solution [1].
  • Microdialysis studies showed that application of orexin A to the TMN increased histamine release from both the medial preoptic area and the frontal cortex by approximately 2-fold over the baseline for 80 to 160 min in a dose-dependent manner [29].

Associations of Microdialysis with chemical compounds

  • In conclusion, our data demonstrate that in situ microdialysis is a useful method for studying the PGE2 production in human bone [12].
  • We used bilateral intrahippocampal microdialysis to test the hypothesis that an increase in extracellular glutamate may trigger spontaneous seizures [30].
  • Hippocampal noradrenaline release after microdialysis and the frequency of abdominal contractions were measured in response to acute colorectal distention [31].
  • Microdialysis studies with 5-HT reuptake inhibitors [32].
  • Upon intracerebroventricular administration, galanin-(1-16) (10 micrograms/15 microliters) also inhibited the scopolamine (0.3 mg/kg, s.c.)-evoked release of acetylcholine, as studied in vivo by microdialysis [33].

Gene context of Microdialysis


Analytical, diagnostic and therapeutic context of Microdialysis


  1. Systemic hypoxia elevates skeletal muscle interstitial adenosine levels in humans. MacLean, D.A., Sinoway, L.I., Leuenberger, U. Circulation (1998) [Pubmed]
  2. Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure. Rose, C., Michalak, A., Pannunzio, M., Chatauret, N., Rambaldi, A., Butterworth, R.F. Hepatology (2000) [Pubmed]
  3. Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release. Borg, W.P., Sherwin, R.S., During, M.J., Borg, M.A., Shulman, G.I. Diabetes (1995) [Pubmed]
  4. Crystal structure of ribonuclease T1 complexed with adenosine 2'-monophosphate at 1.8-A resolution. Ding, J., Koellner, G., Grunert, H.P., Saenger, W. J. Biol. Chem. (1991) [Pubmed]
  5. Regulation of skeletal muscle blood flow during acute insulin-induced hypoglycemia in the rat. Hickner, R.C., Ungerstedt, U., Henriksson, J. Diabetes (1994) [Pubmed]
  6. Dynamic changes in nucleus accumbens dopamine efflux during the Coolidge effect in male rats. Fiorino, D.F., Coury, A., Phillips, A.G. J. Neurosci. (1997) [Pubmed]
  7. The dual peptidase inhibitor RB101 induces a long-lasting increase in the extracellular level of Met-enkephalin-like material in the nucleus accumbens of freely moving rats. Daugé, V., Mauborgne, A., Cesselin, F., Fournié-Zaluski, M.C., Roques, B.P. J. Neurochem. (1996) [Pubmed]
  8. Electroconvulsive shock produces large increases in interstitial concentrations of dopamine in the rat striatum: an in vivo microdialysis study. Nomikos, G.G., Zis, A.P., Damsma, G., Fibiger, H.C. Neuropsychopharmacology (1991) [Pubmed]
  9. Extracellular adenosine in the human brain during sleep and sleep deprivation: an in vivo microdialysis study. Zeitzer, J.M., Morales-Villagran, A., Maidment, N.T., Behnke, E.J., Ackerson, L.C., Lopez-Rodriguez, F., Fried, I., Engel, J., Wilson, C.L. Sleep. (2006) [Pubmed]
  10. Lack of glucocorticoids attenuates the self-stimulation-induced increase in the in vivo synthesis rate of dopamine but not serotonin in the rat nucleus accumbens. Nakahara, D., Nakamura, M., Oki, Y., Ishida, Y. Eur. J. Neurosci. (2000) [Pubmed]
  11. Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. Cline, G.W., Petersen, K.F., Krssak, M., Shen, J., Hundal, R.S., Trajanoski, Z., Inzucchi, S., Dresner, A., Rothman, D.L., Shulman, G.I. N. Engl. J. Med. (1999) [Pubmed]
  12. In situ microdialysis in bone tissue. Stimulation of prostaglandin E2 release by weight-bearing mechanical loading. Thorsen, K., Kristoffersson, A.O., Lerner, U.H., Lorentzon, R.P. J. Clin. Invest. (1996) [Pubmed]
  13. Decreased stress responsivity of central and peripheral catecholaminergic systems in aged 344/N Fischer rats. Cizza, G., Pacak, K., Kvetnansky, R., Palkovits, M., Goldstein, D.S., Brady, L.S., Fukuhara, K., Bergamini, E., Kopin, I.J., Blackman, M.R. J. Clin. Invest. (1995) [Pubmed]
  14. In vivo release of dopa and dopamine from genetically engineered cells grafted to the denervated rat striatum. Horellou, P., Brundin, P., Kalén, P., Mallet, J., Björklund, A. Neuron (1990) [Pubmed]
  15. Plasma binding and transport of diazepam across the blood-brain barrier. No evidence for in vivo enhanced dissociation. Dubey, R.K., McAllister, C.B., Inoue, M., Wilkinson, G.R. J. Clin. Invest. (1989) [Pubmed]
  16. Effect of physiological hyperinsulinemia on blood flow and interstitial glucose concentration in human skeletal muscle and adipose tissue studied by microdialysis. Rosdahl, H., Lind, L., Millgård, J., Lithell, H., Ungerstedt, U., Henriksson, J. Diabetes (1998) [Pubmed]
  17. In vivo evidence of altered skeletal muscle blood flow in chronic tension-type headache. Ashina, M., Stallknecht, B., Bendtsen, L., Pedersen, J.F., Galbo, H., Dalgaard, P., Olesen, J. Brain (2002) [Pubmed]
  18. Polyol-pathway-dependent disturbances in renal medullary metabolism in experimental insulin-deficient diabetes mellitus in rats. Palm, F., Hansell, P., Ronquist, G., Waldenström, A., Liss, P., Carlsson, P.O. Diabetologia (2004) [Pubmed]
  19. Serotonin release into plasma during common carotid artery thrombosis in rats. Wester, P., Dietrich, W.D., Prado, R., Watson, B.D., Globus, M.Y. Stroke (1992) [Pubmed]
  20. Intravascular source of adenosine during forearm ischemia in humans: implications for reactive hyperemia. Costa, F., Sulur, P., Angel, M., Cavalcante, J., Haile, V., Christman, B., Biaggioni, I. Hypertension (1999) [Pubmed]
  21. Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death. Bruno, V., Battaglia, G., Ksiazek, I., van der Putten, H., Catania, M.V., Giuffrida, R., Lukic, S., Leonhardt, T., Inderbitzin, W., Gasparini, F., Kuhn, R., Hampson, D.R., Nicoletti, F., Flor, P.J. J. Neurosci. (2000) [Pubmed]
  22. Major differences in noradrenaline action on lipolysis and blood flow rates in skeletal muscle and adipose tissue in vivo. Quisth, V., Enoksson, S., Blaak, E., Hagström-Toft, E., Arner, P., Bolinder, J. Diabetologia (2005) [Pubmed]
  23. Human adipose tissue glucose uptake determined using [(18)F]-fluoro-deoxy-glucose ([(18)F]FDG) and PET in combination with microdialysis. Virtanen, K.A., Peltoniemi, P., Marjamäki, P., Asola, M., Strindberg, L., Parkkola, R., Huupponen, R., Knuuti, J., Lönnroth, P., Nuutila, P. Diabetologia (2001) [Pubmed]
  24. Brain temperature alters hydroxyl radical production during cerebral ischemia/reperfusion in rats. Kil, H.Y., Zhang, J., Piantadosi, C.A. J. Cereb. Blood Flow Metab. (1996) [Pubmed]
  25. Hypocaloric diet reduces exercise-induced alpha 2-adrenergic antilipolytic effect and alpha 2-adrenergic receptor mRNA levels in adipose tissue of obese women. Stich, V., Marion-Latard, F., Hejnova, J., Viguerie, N., Lefort, C., Suljkovicova, H., Langin, D., Lafontan, M., Berlan, M. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  26. Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens. Pontieri, F.E., Tanda, G., Di Chiara, G. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  27. Prenatal exposure to a cannabinoid agonist produces memory deficits linked to dysfunction in hippocampal long-term potentiation and glutamate release. Mereu, G., Fà, M., Ferraro, L., Cagiano, R., Antonelli, T., Tattoli, M., Ghiglieri, V., Tanganelli, S., Gessa, G.L., Cuomo, V. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  28. Control of cocaine-seeking behavior by drug-associated stimuli in rats: effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens. Weiss, F., Maldonado-Vlaar, C.S., Parsons, L.H., Kerr, T.M., Smith, D.L., Ben-Shahar, O. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  29. Arousal effect of orexin A depends on activation of the histaminergic system. Huang, Z.L., Qu, W.M., Li, W.D., Mochizuki, T., Eguchi, N., Watanabe, T., Urade, Y., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  30. Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. During, M.J., Spencer, D.D. Lancet (1993) [Pubmed]
  31. Corticotropin-releasing hormone receptor 1 antagonist blocks brain-gut activation induced by colonic distention in rats. Saito, K., Kasai, T., Nagura, Y., Ito, H., Kanazawa, M., Fukudo, S. Gastroenterology (2005) [Pubmed]
  32. Microdialysis studies with 5-HT reuptake inhibitors. Fuller, R.W. Trends Pharmacol. Sci. (1993) [Pubmed]
  33. N-terminal galanin-(1-16) fragment is an agonist at the hippocampal galanin receptor. Fisone, G., Berthold, M., Bedecs, K., Undén, A., Bartfai, T., Bertorelli, R., Consolo, S., Crawley, J., Martin, B., Nilsson, S. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  34. Release of vasopressin within the rat paraventricular nucleus in response to emotional stress: a novel mechanism of regulating adrenocorticotropic hormone secretion? Wotjak, C.T., Kubota, M., Liebsch, G., Montkowski, A., Holsboer, F., Neumann, I., Landgraf, R. J. Neurosci. (1996) [Pubmed]
  35. Tamoxifen inhibits secretion of vascular endothelial growth factor in breast cancer in vivo. Garvin, S., Dabrosin, C. Cancer Res. (2003) [Pubmed]
  36. Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. Goldberg, M.S., Fleming, S.M., Palacino, J.J., Cepeda, C., Lam, H.A., Bhatnagar, A., Meloni, E.G., Wu, N., Ackerson, L.C., Klapstein, G.J., Gajendiran, M., Roth, B.L., Chesselet, M.F., Maidment, N.T., Levine, M.S., Shen, J. J. Biol. Chem. (2003) [Pubmed]
  37. Blockade of substance P (neurokinin 1) receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor: an in vivo microdialysis study in mice. Guiard, B.P., Przybylski, C., Guilloux, J.P., Seif, I., Froger, N., De Felipe, C., Hunt, S.P., Lanfumey, L., Gardier, A.M. J. Neurochem. (2004) [Pubmed]
  38. NO-mediated alterations in skeletal muscle nutritive blood flow and lactate metabolism in fibromyalgia. McIver, K.L., Evans, C., Kraus, R.M., Ispas, L., Sciotti, V.M., Hickner, R.C. Pain (2006) [Pubmed]
  39. Evidence for a substrate of neuronal plasticity based on pre- and postsynaptic neurotensin-dopamine receptor interactions in the neostriatum. Fuxe, K., O'Connor, W.T., Antonelli, T., Osborne, P.G., Tanganelli, S., Agnati, L.F., Ungerstedt, U. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  40. The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine. Blay, J., White, T.D., Hoskin, D.W. Cancer Res. (1997) [Pubmed]
  41. Dopaminergic regulation of the serotonergic raphe-striatal pathway: microdialysis studies in freely moving rats. Ferré, S., Cortés, R., Artigas, F. J. Neurosci. (1994) [Pubmed]
  42. Electrical stimulation of the prefrontal cortex increases dopamine release in the nucleus accumbens of the rat: modulation by metabotropic glutamate receptors. Taber, M.T., Fibiger, H.C. J. Neurosci. (1995) [Pubmed]
  43. State-dependent release of acetylcholine in rat thalamus measured by in vivo microdialysis. Williams, J.A., Comisarow, J., Day, J., Fibiger, H.C., Reiner, P.B. J. Neurosci. (1994) [Pubmed]
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