Cloning and sequencing of the bovine gastrin gene.
In order to deduce the primary structure of bovine preprogastrin we therefore sequenced a gastrin DNA clone isolated from a bovine liver cosmid library. Bovine preprogastrin comprises 104 amino acids and consists of a signal peptide, a 37 amino acid spacer-sequence, the gastrin-34 sequence followed by an amidation-site (Gly-Arg-Arg), and a C-terminal nonapeptide. Comparison with human, porcine, and rat cDNA sequences revealed extensive homology in the coding region as well as in short noncoding structures.[1]References
- Cloning and sequencing of the bovine gastrin gene. Lund, T., Olsen, J., Rehfeld, J.F. Mol. Endocrinol. (1989) [Pubmed]
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