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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Synthesis of mono- and bifunctional alpha-methylene lactone systems as potential tumor inhibitors.

Synthetic nono- and bifunctional alpha-methylene lactone derivatives including deoxyvernolepin and kihydrodeoxyvernolepin were tested as inhibitors of the growth of CCRF-CEM human lymphoblastic leukemia cells in culture. The range of ID-50 values for compounds 1-7 (ca. 10(-5)-10(-6)M) was roughly comparable to the doses observed earlier in the CCRF-CEM cell system with synthetic alpha-methylene-gamma-butyrolactones. Of significance is that dihydrodeoxyvernolepin and deoxyvernolepin were at least an order of magnitude more active than natural vernolepin.[1]

References

  1. Synthesis of mono- and bifunctional alpha-methylene lactone systems as potential tumor inhibitors. Grieco, P.A., Noguez, J.A., Masaki, Y., Hiroi, Y., Nishizawa, M., Rosowsky, A., Oppenheim, S., Lazarus, H. J. Med. Chem. (1977) [Pubmed]
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