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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Adverse effects of fenfluramine in treatment refractory schizophrenia.

Fenfluramine was administered to eight severely ill schizophrenic patients as an adjunct to neuroleptic drugs in a double-blind, multiple baseline design. A significant adverse effect of fenfluramine on psychopathology was detected through nurses' ratings, target symptom scales, the Brief Psychiatric Rating Scale, and time-sampled behavioral observations. Clinical deterioration was correlated with fenfluramine-induced reductions in blood serotonin levels and persisted beyond the point of discontinuation of fenfluramine.[1]

References

  1. Adverse effects of fenfluramine in treatment refractory schizophrenia. Marshall, B.D., Glynn, S.M., Midha, K.K., Hubbard, J.W., Bowen, L.L., Banzett, L., Mintz, J., Liberman, R.P. Journal of clinical psychopharmacology. (1989) [Pubmed]
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