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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

The CUP2 gene product, regulator of yeast metallothionein expression, is a copper-activated DNA-binding protein.

CUP2 is a regulatory gene controlling expression of CUP1, which encodes the Cu-binding yeast metallothionein. CUP2, which is identical to the ACE1 gene, encodes a Cu-regulated DNA-binding protein. The CUP2 protein contains a cysteine-rich DNA-binding domain dependent on Cu+ and Ag+ ions which bind the cysteine residues and direct the refolding of the metal-free apoprotein. CUP2 mutant alleles from Cu-sensitive yeast strains have point mutations affecting the DNA-binding activity. These results establish CUP2 as the primary sensor of intracellular Cu+ in the yeast Saccharomyces cerevisiae, functioning as a Cu+-regulated transcriptional activator.[1]

References

  1. The CUP2 gene product, regulator of yeast metallothionein expression, is a copper-activated DNA-binding protein. Buchman, C., Skroch, P., Welch, J., Fogel, S., Karin, M. Mol. Cell. Biol. (1989) [Pubmed]
 
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