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Morris, D.R. et al.

Transforming growth factor-beta blocks proliferation but not early mitogenic signaling events in T-lymphocytes.

Transforming growth factor-beta (TGF-beta) inhibits the proliferation of T-lymphocytes in response to activation with mitogenic lectin. The influence of TGF-beta on elevation of cytosolic Ca2+, induction of proliferation-associated mRNA species, and total cellular RNA content has been studied. The cells seem to exit G0 when activated in the presence of TGF-beta, but they arrest in mid-G1 phase.[1]

References

Transforming growth factor-beta blocks proliferation but not early mitogenic signaling events in T-lymphocytes. Morris, D.R., Kuepfer, C.A., Ellingsworth, L.R., Ogawa, Y., Rabinovitch, P.S. Exp. Cell Res. (1989) [Pubmed]

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