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TGF1  -  transforming growth factor 1

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Disease relevance of TGF1


High impact information on TGF1


Biological context of TGF1


Anatomical context of TGF1


Associations of TGF1 with chemical compounds


Regulatory relationships of TGF1


Other interactions of TGF1


Analytical, diagnostic and therapeutic context of TGF1


  1. Vaccinia virus 19-kilodalton protein: relationship to several mammalian proteins, including two growth factors. Blomquist, M.C., Hunt, L.T., Barker, W.C. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  2. Transforming growth factor-beta-induced growth inhibition and cellular hypertrophy in cultured vascular smooth muscle cells. Owens, G.K., Geisterfer, A.A., Yang, Y.W., Komoriya, A. J. Cell Biol. (1988) [Pubmed]
  3. Renal fibrosis. Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cells. Zeisberg, M., Maeshima, Y., Mosterman, B., Kalluri, R. Am. J. Pathol. (2002) [Pubmed]
  4. Transforming growth factor-beta enhances adhesion of melanoma cells to the endothelium in vitro. Teti, A., De Giorgi, A., Spinella, M.T., Migliaccio, S., Canipari, R., Onetti Muda, A., Faraggiana, T. Int. J. Cancer (1997) [Pubmed]
  5. RhoA and Rho-kinase dependent and independent signals mediate TGF-beta-induced pulmonary endothelial cytoskeletal reorganization and permeability. Clements, R.T., Minnear, F.L., Singer, H.A., Keller, R.S., Vincent, P.A. Am. J. Physiol. Lung Cell Mol. Physiol. (2005) [Pubmed]
  6. Transforming growth factor-beta 1 is decreased in remodeling hypertensive bovine pulmonary arteries. Botney, M.D., Parks, W.C., Crouch, E.C., Stenmark, K., Mecham, R.P. J. Clin. Invest. (1992) [Pubmed]
  7. Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro. Pepper, M.S., Belin, D., Montesano, R., Orci, L., Vassalli, J.D. J. Cell Biol. (1990) [Pubmed]
  8. In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases. Mignatti, P., Tsuboi, R., Robbins, E., Rifkin, D.B. J. Cell Biol. (1989) [Pubmed]
  9. Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro. Robey, P.G., Young, M.F., Flanders, K.C., Roche, N.S., Kondaiah, P., Reddi, A.H., Termine, J.D., Sporn, M.B., Roberts, A.B. J. Cell Biol. (1987) [Pubmed]
  10. Transforming growth factor beta1 induction of vascular endothelial growth factor receptor 1: mechanism of pericyte-induced vascular survival in vivo. Shih, S.C., Ju, M., Liu, N., Mo, J.R., Ney, J.J., Smith, L.E. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  11. Terminal differentiation and calcification in rabbit chondrocyte cultures grown in centrifuge tubes: regulation by transforming growth factor beta and serum factors. Kato, Y., Iwamoto, M., Koike, T., Suzuki, F., Takano, Y. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  12. Electric field-directed cell motility involves up-regulated expression and asymmetric redistribution of the epidermal growth factor receptors and is enhanced by fibronectin and laminin. Zhao, M., Dick, A., Forrester, J.V., McCaig, C.D. Mol. Biol. Cell (1999) [Pubmed]
  13. Transforming growth factor beta 1-mediated inhibition of smooth muscle cell proliferation is associated with a late G1 cell cycle arrest. Reddy, K.B., Howe, P.H. J. Cell. Physiol. (1993) [Pubmed]
  14. Regulation by growth factors of angiotensin II type-1 receptor and the alpha subunit of Gq and G11 in bovine adrenal cells. Langlois, D., Ouali, R., Berthelon, M.C., Derrien, A., Saez, J.M. Endocrinology (1994) [Pubmed]
  15. Effects of transforming growth factor-beta 1 on growth of aortic smooth muscle cells. Influences of interaction with growth factors, cell state, cell phenotype, and cell cycle. Morisaki, N., Kawano, M., Koyama, N., Koshikawa, T., Umemiya, K., Saito, Y., Yoshida, S. Atherosclerosis (1991) [Pubmed]
  16. Transforming growth factor-beta 1 and forskolin modulate gap junctional communication and cellular phenotype of cultured Schwann cells. Chandross, K.J., Chanson, M., Spray, D.C., Kessler, J.A. J. Neurosci. (1995) [Pubmed]
  17. Covalent and non-covalent interactions of betaig-h3 with collagen VI. Beta ig-h3 is covalently attached to the amino-terminal region of collagen VI in tissue microfibrils. Hanssen, E., Reinboth, B., Gibson, M.A. J. Biol. Chem. (2003) [Pubmed]
  18. Transforming growth factor beta1 decreases cholesterol supply to mitochondria via repression of steroidogenic acute regulatory protein expression. Brand, C., Cherradi, N., Defaye, G., Chinn, A., Chambaz, E.M., Feige, J.J., Bailly, S. J. Biol. Chem. (1998) [Pubmed]
  19. Transforming growth factor-alpha expression in the anterior pituitary gland: regulation by epidermal growth factor and phorbol ester in dispersed cells. Mueller, S.G., Kobrin, M.S., Paterson, A.J., Kudlow, J.E. Mol. Endocrinol. (1989) [Pubmed]
  20. Transforming growth factor-beta blocks proliferation but not early mitogenic signaling events in T-lymphocytes. Morris, D.R., Kuepfer, C.A., Ellingsworth, L.R., Ogawa, Y., Rabinovitch, P.S. Exp. Cell Res. (1989) [Pubmed]
  21. Transforming growth factor-beta 1 inhibits aldosterone biosynthesis in cultured bovine zona glomerulosa cells. Gupta, P., Franco-Saenz, R., Mulrow, P.J. Endocrinology (1993) [Pubmed]
  22. Transforming growth factor beta 1 is a negative regulator of steroid 17 alpha-hydroxylase expression in bovine adrenocortical cells. Perrin, A., Pascal, O., Defaye, G., Feige, J.J., Chambaz, E.M. Endocrinology (1991) [Pubmed]
  23. Transforming growth factor beta 1 and adrenocorticotropin differentially regulate the synthesis of adrenocortical cell heparan sulfate proteoglycans and their binding of basic fibroblast growth factor. Jiang, Z., Savona, C., Chambaz, E.M., Feige, J.J. J. Cell. Physiol. (1992) [Pubmed]
  24. Transforming growth factor-beta 1 and ascorbate regulate proliferation of cultured smooth muscle cells by independent mechanisms. Ivanov, V.O., Rabovsky, A.B., Ivanova, S.V., Niedzwiecki, A. Atherosclerosis (1998) [Pubmed]
  25. Transforming growth factor-beta stimulates retinoic acid-induced proteoglycan depletion in intact articular cartilage. Von den Hoff, H.W., de Koning, M.H., van Kampen, G.P., van der Korst, J.K. Arch. Biochem. Biophys. (1994) [Pubmed]
  26. Transforming growth factor beta1 regulates follistatin mRNA expression during in vitro bovine granulosa cell differentiation. Fazzini, M., Vallejo, G., Colman-Lerner, A., Trigo, R., Campo, S., Barañao, J.L., Saragüeta, P.E. J. Cell. Physiol. (2006) [Pubmed]
  27. Transforming growth factor-beta 1 inhibits aldosterone and stimulates adrenal renin in cultured bovine zona glomerulosa cells. Gupta, P., Franco-Saenz, R., Gentry, L.E., Mulrow, P.J. Endocrinology (1992) [Pubmed]
  28. Expression and action of transforming growth factor alpha in normal ovarian surface epithelium and ovarian cancer. Doraiswamy, V., Parrott, J.A., Skinner, M.K. Biol. Reprod. (2000) [Pubmed]
  29. Transforming growth factor-beta and insulin-like growth factor-1 restore proteoglycan metabolism of bovine articular cartilage after depletion by retinoic acid. Morales, T.I. Arch. Biochem. Biophys. (1994) [Pubmed]
  30. Staphylococcus aureus intramammary infection elicits increased production of transforming growth factor-alpha, beta1, and beta2. Bannerman, D.D., Paape, M.J., Chockalingam, A. Vet. Immunol. Immunopathol. (2006) [Pubmed]
  31. Transforming growth factor beta1 blocks the release of collagen fragments from boving nasal cartilage stimulated by oncostatin M in combination with IL-1alpha. Hui, W., Rowan, A.D., Cawston, T. Cytokine (2000) [Pubmed]
  32. Transforming growth factor-alpha: identification in bovine corpus luteum by immunohistochemistry and northern blot analysis. Lobb, D.K., Dorrington, J.H. Reprod. Fertil. Dev. (1993) [Pubmed]
  33. alpha2HS-glycoprotein, an antagonist of transforming growth factor beta in vivo, inhibits intestinal tumor progression. Swallow, C.J., Partridge, E.A., Macmillan, J.C., Tajirian, T., DiGuglielmo, G.M., Hay, K., Szweras, M., Jahnen-Dechent, W., Wrana, J.L., Redston, M., Gallinger, S., Dennis, J.W. Cancer Res. (2004) [Pubmed]
  34. Transforming growth factor beta regulates the metabolism of proteoglycans in bovine cartilage organ cultures. Morales, T.I., Roberts, A.B. J. Biol. Chem. (1988) [Pubmed]
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