Contribution of hydroxyapatite to the tensile strength of the isobutyl-2-cyanoacrylate-bone bond.
The bonding strength between bone and alpha-2-cyanoacrylate polymers, with or without the addition of powdered hydroxyapatite, was determined. The tensile strength of a bone-cyanoacrylate bond was measured for each polymer: 4.31 +/- 0.88 MPa (methyl-), 5.74 +/- 0.62 MPa (ethyl-), and 8.33 +/- 0.41 MPa (isobutyl-). The tensile strength of the isobutyl-2-cyanoacrylate bond increased to 12.03 +/- 0.72 MPa with the addition of 10% (w/v) hydroxyapatite before decreasing to 7.89 +/- 0.58 MPa on addition of 15% (w/v) hydroxyapatite. An optimal concentration of hydroxyapatite significantly increased the tensile strength of a bone-cyanocacrylate bond in vitro in a manner comparable to reinforced bone replacement materials.[1]References
- Contribution of hydroxyapatite to the tensile strength of the isobutyl-2-cyanoacrylate-bone bond. Papatheofanis, F.J. Biomaterials (1989) [Pubmed]
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