Disease relevance of Tensile Strength

• Heterogeneity of tensile strength and matrix metalloproteinase activity in the wall of abdominal aortic aneurysms [1].
• Wound tensile strength and energy absorption were not affected by chronic iron-deficiency anemia, the chronic hemolytic anemia caused by intravenous water infusion nor by chronic hemolytic anemia caused by intravenous water infusion nor by chronic phenylhydrazine-induced anemia [2].
• Ultimate tensile strengths for reconstituted fibres cross-linked with glutaraldehyde ranged from 50 to 66 MPa while those cross-linked by severe dehydration and carbodiimide treatment had ultimate tensile strengths between 24 and 31 MPa [3].
• In the chemical peritonitis model, administration of NM also significantly prevented the loss of tensile strength on Day 3 without disappearance of collagen fibers [4].
• OBJECTIVES: The aim of this study is to count the dentinal tubules in the coronal and middle-apical third of root dentin of teeth extracted due to the progression of periodontal disease, and to compare the Ultimate Tensile Strength (UTS) of the same areas [5].

High impact information on Tensile Strength

• Link protein (LP), an extracellular matrix protein in cartilage, stabilizes aggregates of aggrecan and hyaluronan, giving cartilage its tensile strength and elasticity [6].
• Fast on and off rates, together with the high tensile strength of the selectin bond, appear necessary to support rolling at physiological shear stresses [7].
• The extent of wound repair, as evidenced by enhanced tensile strength, can be markedly improved in tissues transfected with TGF-beta1 expression constructs [8].
• It is concluded that semicarbazide may selectively impair the maturation of lung collagen and that immaturity of lung collagen is associated with a reduction in the tensile strength of lung tissue, without changes in elasticity within physiological volume limits [9].
• A fast off rate and the low tensile strength of the E-cadherin bond may be necessary to support the high selectivity and plasticity of epithelial cell interactions [10].

Chemical compound and disease context of Tensile Strength

• CONCLUSION: The increase in COX-2 expression attributable to hypoxia and the tensile strength of bladder wall was attenuated by celecoxib [11].
• This study highlights the effects of some physical and chemical methods of sterilization on chitosan films, in retaining the original tensile strength besides the efficacy of sterility and degree of hemolysis of the finished films [12].
• Fluoride administration did not affect the torsion or bending strength of the bones of guinea pigs fed normal diets but increased the tensile strength [13].
• Using tensile strength and tendon lengthening until gap formation as measurement parameters, these three types of repair were tested in human flexor and extensor tendons from fresh cadavers [14].
• The tensile strength of the bowel wall is impaired in elderly patients, patients receiving long-term steroid therapy, and in disease states including neoplasm, diverticulitis, inflammatory bowel disease, and ischemia [15].

Biological context of Tensile Strength

• Exogenous addition of neutralising antibody to TGF-beta to incisional wounds reduced the inflammatory and angiogenic responses and reduced the extracellular matrix deposition in the early stages of wound healing without reducing the tensile strength of the wounds [16].
• There was no mortality among male and female turkeys fed the control diet or significant differences in blood pressure, heart rate, aortic tensile strength, or aortic hydroxyproline between these males and females [17].
• Test parameters were weight development, testosterone, parathyroid hormone, vitamin D, osteocalcin, cross links, hydroxyproline and cyclic adenosine monophosphate as well as bone density, tensile strength, mineral content and histomorphometry [18].
• Parameters monitored were time to complete wound closure, wound hydroxyproline content and tensile strength, as well as histology [19].
• Prostaglandin E2 treatment before day 20 of gestation produced no change in cervical tensile strength [20].

Anatomical context of Tensile Strength

• Hence, besides its contribution to the bond energy, the Ca2+ ion also grants the selectin-sLeX complexes a tensile strength that is crucial for the selectin-mediated rolling of leukocytes [21].
• However, once fibronectin-treated collagen biogels were fully contracted, the actin cytoskeleton no longer contributed to the tensile strength [22].
• The observed sequence of connective tissue proteins reflects the particular function that each carries out during muscle wound healing (e.g., fibronectin in fibroblast trapping, type III collagen in plasticity/flexibility, and type I collagen in tensile strength) [23].
• At maturity the pig digital flexor tendons have twice the tensile strength and elastic modulus but only half the strain energy dissipation of the corresponding extensor tendons [24].
• During granulation tissue formation, fibronectin provides a temporary substratum for migration and proliferation of cells and provides a template for collagen deposition, which increases stiffness and tensile strength of this healing tissues [25].

Associations of Tensile Strength with chemical compounds

• A progressive decrease in collagen deposition on polyvinyl alcohol sponge and wounded skin tensile strength was seen as a function of the duration of diabetes [26].
• Formation of aldehyde intermediates and cross-links during fibril formation may facilitate the biosynthesis of stable collagen fibrils and contribute to increased fibril tensile strength in vivo [27].
• The differences in hydrolytic degradation of two size 2-0 synthetic absorbable sutures, Polyglycolic acid (Dexon) and Poly(glycolide-lactide) (Vicryl), in the buffer media of three different pH levels ranging from 5.25 to 10.09, were compared in terms of the percentage retention of tensile strength [28].
• The higher aortic tensile strength that was produced by propranolol did not persist [29].
• Our single-molecule force spectroscopy measurements reveal that type II VE-cadherin molecules form bonds that are less prone to rupture and display a higher tensile strength than bonds formed by classical type I neuronal (N) cadherin and epithelial (E) cadherin [30].

Gene context of Tensile Strength

• Although no gross visible differences were noted among healed wounds of the different mouse types, measurement of tensile strength showed that both PGHS-1 and PGHS-2 null wounds were weaker (75% and 70%, respectively) than wild-type wounds at 12 days after incision [31].
• LH hydroxylates specific lysine residues in the collagen molecule that are precursors for the formation of cross-links which provide collagen with its tensile strength [32].
• Tensiometry was used to measure the tensile strength of incisional wounds over a 60-day time course; overall, Hoxb13 KO wounds are significantly stronger than wild-type (WT) [33].
• We report that mice harboring a targeted disruption of the decorin gene are viable but have fragile skin with markedly reduced tensile strength [34].
• Despite this severe structural alteration, mur3 plants were phenotypically normal and exhibited tensile strength in their inflorescence stems comparable to that of wild-type plants [35].

Analytical, diagnostic and therapeutic context of Tensile Strength

• We systematically investigated the healing canine end-to-end choledochal anastomosis and tested the hypothesis that common bile duct anastomoses sutured with monofilament polyglyconate absorbable suture would heal with less stricture formation and greater tensile strength than those sutured with braided polyglactin 910 and chromic catgut sutures [36].
• For xenografts cross-linked with GA for seven days, similar increases in tensile strength of tenorrhaphies, with the two types of TAD were found [37].
• Differential scanning calorimetry and dynamic mechanical analysis showed that the polymer with the highest phosphorylcholine content (PU-GPC-20) had the lowest soft segment Tg and the highest tensile strength and Young's modulus among the polymers studied [38].
• METHODS: Standardized specimens consisting of Palacos cement combined with liquid gentamicin, powdered tobramycin, or no antibiotic were fashioned, and the three groups were tested with regard to compressive and tensile strength, elution characteristics (with use of radioimmunoassays), and antibacterial activity (with use of bioassays) [39].
• We have studied the immunohistochemistry of extracellular matrix to investigate changes associated with this loss of tensile strength [40].

References