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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Tensile Strength

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Disease relevance of Tensile Strength


High impact information on Tensile Strength

  • Link protein (LP), an extracellular matrix protein in cartilage, stabilizes aggregates of aggrecan and hyaluronan, giving cartilage its tensile strength and elasticity [6].
  • Fast on and off rates, together with the high tensile strength of the selectin bond, appear necessary to support rolling at physiological shear stresses [7].
  • The extent of wound repair, as evidenced by enhanced tensile strength, can be markedly improved in tissues transfected with TGF-beta1 expression constructs [8].
  • It is concluded that semicarbazide may selectively impair the maturation of lung collagen and that immaturity of lung collagen is associated with a reduction in the tensile strength of lung tissue, without changes in elasticity within physiological volume limits [9].
  • A fast off rate and the low tensile strength of the E-cadherin bond may be necessary to support the high selectivity and plasticity of epithelial cell interactions [10].

Chemical compound and disease context of Tensile Strength


Biological context of Tensile Strength


Anatomical context of Tensile Strength


Associations of Tensile Strength with chemical compounds

  • A progressive decrease in collagen deposition on polyvinyl alcohol sponge and wounded skin tensile strength was seen as a function of the duration of diabetes [26].
  • Formation of aldehyde intermediates and cross-links during fibril formation may facilitate the biosynthesis of stable collagen fibrils and contribute to increased fibril tensile strength in vivo [27].
  • The differences in hydrolytic degradation of two size 2-0 synthetic absorbable sutures, Polyglycolic acid (Dexon) and Poly(glycolide-lactide) (Vicryl), in the buffer media of three different pH levels ranging from 5.25 to 10.09, were compared in terms of the percentage retention of tensile strength [28].
  • The higher aortic tensile strength that was produced by propranolol did not persist [29].
  • Our single-molecule force spectroscopy measurements reveal that type II VE-cadherin molecules form bonds that are less prone to rupture and display a higher tensile strength than bonds formed by classical type I neuronal (N) cadherin and epithelial (E) cadherin [30].

Gene context of Tensile Strength

  • Although no gross visible differences were noted among healed wounds of the different mouse types, measurement of tensile strength showed that both PGHS-1 and PGHS-2 null wounds were weaker (75% and 70%, respectively) than wild-type wounds at 12 days after incision [31].
  • LH hydroxylates specific lysine residues in the collagen molecule that are precursors for the formation of cross-links which provide collagen with its tensile strength [32].
  • Tensiometry was used to measure the tensile strength of incisional wounds over a 60-day time course; overall, Hoxb13 KO wounds are significantly stronger than wild-type (WT) [33].
  • We report that mice harboring a targeted disruption of the decorin gene are viable but have fragile skin with markedly reduced tensile strength [34].
  • Despite this severe structural alteration, mur3 plants were phenotypically normal and exhibited tensile strength in their inflorescence stems comparable to that of wild-type plants [35].

Analytical, diagnostic and therapeutic context of Tensile Strength


  1. Heterogeneity of tensile strength and matrix metalloproteinase activity in the wall of abdominal aortic aneurysms. Vallabhaneni, S.R., Gilling-Smith, G.L., How, T.V., Carter, S.D., Brennan, J.A., Harris, P.L. J. Endovasc. Ther. (2004) [Pubmed]
  2. Chronic anemia, wound healing, and red cell 2,3-diphosphoglycerate. Fong, T.P., Ko, S.T., Streczyn, M., Westerman, M.P. Surgery (1976) [Pubmed]
  3. Mechanical properties of collagen fibres: a comparison of reconstituted and rat tail tendon fibres. Kato, Y.P., Christiansen, D.L., Hahn, R.A., Shieh, S.J., Goldstein, J.D., Silver, F.H. Biomaterials (1989) [Pubmed]
  4. Protease inhibitor reduces loss of tensile strength in rat anastomosis with peritonitis. Tani, T., Tsutamoto, Y., Eguchi, Y., Araki, H., Ebira, Y., Ameno, H., Fujino, M., Oka, H., Kodama, M. J. Surg. Res. (2000) [Pubmed]
  5. Density of dentinal tubules affects the tensile strength of root dentin. Mannocci, F., Pilecki, P., Bertelli, E., Watson, T.F. Dental materials : official publication of the Academy of Dental Materials. (2004) [Pubmed]
  6. Mice lacking link protein develop dwarfism and craniofacial abnormalities. Watanabe, H., Yamada, Y. Nat. Genet. (1999) [Pubmed]
  7. Lifetime of the P-selectin-carbohydrate bond and its response to tensile force in hydrodynamic flow. Alon, R., Hammer, D.A., Springer, T.A. Nature (1995) [Pubmed]
  8. Particle-mediated gene transfer with transforming growth factor-beta1 cDNAs enhances wound repair in rat skin. Benn, S.I., Whitsitt, J.S., Broadley, K.N., Nanney, L.B., Perkins, D., He, L., Patel, M., Morgan, J.R., Swain, W.F., Davidson, J.M. J. Clin. Invest. (1996) [Pubmed]
  9. Effects of a molecular change in collagen on lung structure and mechanical function. Stanley, N.N., Alper, R., Cunningham, E.L., Cherniack, N.S., Kefalides, N.A. J. Clin. Invest. (1975) [Pubmed]
  10. Fast dissociation kinetics between individual E-cadherin fragments revealed by flow chamber analysis. Perret, E., Benoliel, A.M., Nassoy, P., Pierres, A., Delmas, V., Thiery, J.P., Bongrand, P., Feracci, H. EMBO J. (2002) [Pubmed]
  11. The restorative effect of a selective cyclooxygenase-2 inhibitor on urothelial cell-cell interactions after partial bladder outlet obstruction in rats. Erdogru, T., Celik-Ozenci, C., Seval, Y., Emreoglu, I., Ustunel, I., Korgun, E., Koksal, T.I., Baykara, M., Demir, R. BJU international. (2005) [Pubmed]
  12. Sterilization of chitosan: implications. Rao, S.B., Sharma, C.P. Journal of biomaterials applications. (1995) [Pubmed]
  13. The interaction of dietary vitamin C, protein, and calcium with fluoride: effects in guinea pigs in relation to breaking strength and radiodensity of bone. Parker, C.M., Sharma, R.P., Shupe, J.L. Clin. Toxicol. (1979) [Pubmed]
  14. Cross stitch peripheral tendon repair: a mechanical comparison with core stitch techniques. Papaloïzos, M.Y., Schärer, N., Rehart, S., Stüssi, E., Meyer, V.E. Chirurgie de la main. (2000) [Pubmed]
  15. Recognition and prevention of barium enema complications. Williams, S.M., Harned, R.K. Current problems in diagnostic radiology. (1991) [Pubmed]
  16. Neutralising antibody to TGF-beta 1,2 reduces cutaneous scarring in adult rodents. Shah, M., Foreman, D.M., Ferguson, M.W. J. Cell. Sci. (1994) [Pubmed]
  17. Mortality, hemodynamics, and aortic properties among male and female turkeys fed beta-aminopropionitrile. Simpson, C.F., Cardeilhac, P.T. Proc. Soc. Exp. Biol. Med. (1983) [Pubmed]
  18. Osteoporosis and mild metabolic acidosis in the rat after orchiectomy and their prevention: should prophylactic therapy be administered to patients with androgen deprivation? Straub, B., Müller, M., Schrader, M., Heicappell, R., Miller, K. J. Urol. (2001) [Pubmed]
  19. Oxandrolone, an anabolic steroid, enhances the healing of a cutaneous wound in the rat. Demling, R.H. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. (2000) [Pubmed]
  20. Expression of matrix metalloproteinase-3 in the rat cervix during pregnancy and in response to prostaglandin E2. Chien, E.K., Ji, H., Feltovich, H., Clark, K. Am. J. Obstet. Gynecol. (2005) [Pubmed]
  21. Molecular basis of the dynamic strength of the sialyl Lewis X--selectin interaction. Zhang, X., Bogorin, D.F., Moy, V.T. Chemphyschem : a European journal of chemical physics and physical chemistry. (2004) [Pubmed]
  22. Fibronectin matrix polymerization increases tensile strength of model tissue. Gildner, C.D., Lerner, A.L., Hocking, D.C. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  23. Localization of type I and III collagen and fibronectin production in injured gastrocnemius muscle. Hurme, T., Kalimo, H., Sandberg, M., Lehto, M., Vuorio, E. Lab. Invest. (1991) [Pubmed]
  24. Elastic energy storage in tendons: mechanical differences related to function and age. Shadwick, R.E. J. Appl. Physiol. (1990) [Pubmed]
  25. Biocompatible nanofiber matrices for the engineering of a dermal substitute for skin regeneration. Venugopal, J., Ramakrishna, S. Tissue engineering. (2005) [Pubmed]
  26. Glucocorticoid dynamics and impaired wound healing in diabetes mellitus. Bitar, M.S. Am. J. Pathol. (1998) [Pubmed]
  27. Collagen cross-linking. Purification and substrate specificity of lysyl oxidase. Siegel, R.C., Fu, J.C. J. Biol. Chem. (1976) [Pubmed]
  28. A comparison of the effect of pH on the biodegradation of two synthetic absorbable sutures. Chu, C.C. Ann. Surg. (1982) [Pubmed]
  29. Propranolol effects on hypertension and the arterial wall beyond the treatment period in turkeys. Simpson, C.F., Taylor, W.J. Hypertension (1983) [Pubmed]
  30. Probing intercellular interactions between vascular endothelial cadherin pairs at single-molecule resolution and in living cells. Panorchan, P., George, J.P., Wirtz, D. J. Mol. Biol. (2006) [Pubmed]
  31. Both constitutive and inducible prostaglandin H synthase affect dermal wound healing in mice. Laulederkind, S.J., Thompson-Jaeger, S., Goorha, S., Chen, Q., Fu, A., Rho, J.Y., Ballou, L.R., Raghow, R. Lab. Invest. (2002) [Pubmed]
  32. Decreased expression of lysyl hydroxylase 2 (LH2) in skin fibroblasts from three Ehlers-Danlos patients does not result from mutations in either the coding or proximal promoter region of the LH2 gene. Walker, L.C., Teebi, A.S., Marini, J.C., De Paepe, A., Malfait, F., Atsawasuwan, P., Yamauchi, M., Yeowell, H.N. Mol. Genet. Metab. (2004) [Pubmed]
  33. Hoxb13 knockout adult skin exhibits high levels of hyaluronan and enhanced wound healing. Mack, J.A., Abramson, S.R., Ben, Y., Coffin, J.C., Rothrock, J.K., Maytin, E.V., Hascall, V.C., Largman, C., Stelnicki, E.J. FASEB J. (2003) [Pubmed]
  34. Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility. Danielson, K.G., Baribault, H., Holmes, D.F., Graham, H., Kadler, K.E., Iozzo, R.V. J. Cell Biol. (1997) [Pubmed]
  35. The MUR3 gene of Arabidopsis encodes a xyloglucan galactosyltransferase that is evolutionarily related to animal exostosins. Madson, M., Dunand, C., Li, X., Verma, R., Vanzin, G.F., Caplan, J., Shoue, D.A., Carpita, N.C., Reiter, W.D. Plant Cell (2003) [Pubmed]
  36. Common bile duct healing. Do different absorbable sutures affect stricture formation and tensile strength? Sharp, K.W., Ross, C.B., Tillman, V.N., Dunn, J.F. Archives of surgery (Chicago, Ill. : 1960) (1989) [Pubmed]
  37. Resorbable and non-resorbable augmentation devices for tenorrhaphy of xenografts in extensor tendon deficits: 12 week study. Madden, K.N., Johnson, K.A., Howlett, C.R., Milthorpe, B.K., Robins, G., Ikada, Y., Schindhelm, K. Biomaterials (1997) [Pubmed]
  38. Neutrophil adhesion on phosphorylcholine-containing polyurethanes. Yung, L.Y., Cooper, S.L. Biomaterials (1998) [Pubmed]
  39. Liquid gentamicin in bone cement: a laboratory study of a potentially more cost-effective cement spacer. Seldes, R.M., Winiarsky, R., Jordan, L.C., Baldini, T., Brause, B., Zodda, F., Sculco, T.P. The Journal of bone and joint surgery. American volume. (2005) [Pubmed]
  40. Protective effect of nafamostat mesilate in early wound healing. Tsutamoto, Y., Tani, T., Eguchi, Y., Araki, H., Kodama, M. J. Am. Coll. Surg. (1997) [Pubmed]
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