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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Structure of a mutagen from roasted seeds of Moringa oleifera.

A mutagenic compound was isolated from roasted seeds of Moringa oleifera Lam. Its structure has been elucidated by spectral analysis as 4(alpha-L-rhamnosyloxy)phenylacetonitrile. The results of the Micronucleus Test, an in vivo method, showed that the number of micronucleated polychromatic erythrocytes (PCE)/1000 PCE for this compound is higher than that of the solvent control, dimethylsulfoxide, and approximates that of the positive control, tetracycline. This indicates that 4(alpha-L-rhamnosyloxy)phenylacetonitrile is a genotoxic compound.[1]


  1. Structure of a mutagen from roasted seeds of Moringa oleifera. Villasenor, I.M., Finch, P., Lim-Sylianco, C.Y., Dayrit, F. Carcinogenesis (1989) [Pubmed]
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