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Chemical Compound Review

tetracycline     (2E,4aS,5aS,6S,12aS)-2- (amino-hydroxy...

Synonyms:
 
 
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Disease relevance of tetracycline

 

Psychiatry related information on tetracycline

 

High impact information on tetracycline

 

Chemical compound and disease context of tetracycline

 

Biological context of tetracycline

 

Anatomical context of tetracycline

 

Associations of tetracycline with other chemical compounds

 

Gene context of tetracycline

  • Wolbachia extracts derived from a mosquito cell line induced similar LPS-dependent TNF-alpha and NO responses from C3H/HeN macrophages, which were eliminated after tetracycline treatment of the bacteria [35].
  • No tumor growth could be observed in mice that received mock-transfected clones or tetracycline to block expression of the E2F mutant constructs in vivo [36].
  • Using a tetracycline-regulated LMP-1 allele, we demonstrate that JNK is also an effector of non-cytotoxic LMP-1 signaling in B cells, the physiological target cells of EBV [37].
  • To test its functional properties, we developed osteosarcoma cell lines expressing WT1 under an inducible tetracycline-regulated promoter [38].
  • We established clonal tetracycline-regulated NIH-3T3 cell lines that inducibly express either wild-type Pak1, a kinase-dead, or constitutively-active forms of this enzyme, and examined the morphology, F-actin organization, and motility of these cells [39].
 

Analytical, diagnostic and therapeutic context of tetracycline

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  38. WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis. Englert, C., Hou, X., Maheswaran, S., Bennett, P., Ngwu, C., Re, G.G., Garvin, A.J., Rosner, M.R., Haber, D.A. EMBO J. (1995) [Pubmed]
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