The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

tetracycline     (2E,4aS,5aS,6S,12aS)-2- (amino-hydroxy...

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of tetracycline


Psychiatry related information on tetracycline


High impact information on tetracycline


Chemical compound and disease context of tetracycline


Biological context of tetracycline


Anatomical context of tetracycline


Associations of tetracycline with other chemical compounds


Gene context of tetracycline

  • Wolbachia extracts derived from a mosquito cell line induced similar LPS-dependent TNF-alpha and NO responses from C3H/HeN macrophages, which were eliminated after tetracycline treatment of the bacteria [35].
  • No tumor growth could be observed in mice that received mock-transfected clones or tetracycline to block expression of the E2F mutant constructs in vivo [36].
  • Using a tetracycline-regulated LMP-1 allele, we demonstrate that JNK is also an effector of non-cytotoxic LMP-1 signaling in B cells, the physiological target cells of EBV [37].
  • To test its functional properties, we developed osteosarcoma cell lines expressing WT1 under an inducible tetracycline-regulated promoter [38].
  • We established clonal tetracycline-regulated NIH-3T3 cell lines that inducibly express either wild-type Pak1, a kinase-dead, or constitutively-active forms of this enzyme, and examined the morphology, F-actin organization, and motility of these cells [39].

Analytical, diagnostic and therapeutic context of tetracycline


  1. Adjacent repeating units of Xenopus laevis 5S DNA can be heterogeneous in length. Carroll, D., Brown, D.D. Cell (1976) [Pubmed]
  2. Tetracycline-resistant Neisseria. Brewer, F., Matuszak, D.L., Libonati, J.P., Jackman, N.E., Israel, E. N. Engl. J. Med. (1986) [Pubmed]
  3. Emergence of multidrug-resistant Salmonella enterica serotype typhimurium DT104 infections in the United States. Glynn, M.K., Bopp, C., Dewitt, W., Dabney, P., Mokhtar, M., Angulo, F.J. N. Engl. J. Med. (1998) [Pubmed]
  4. Nearly precise excision: a new type of DNA alteration associated with the translocatable element Tn10. Ross, D.G., Swan, J., Kleckner, N. Cell (1979) [Pubmed]
  5. Spectinomycin versus tetracycline for the treatment of gonorrhea. Karney, W.W., Pedersen, A.H., Nelson, M., Adams, H., Pfeifer, R.T., Holmes, K.K. N. Engl. J. Med. (1977) [Pubmed]
  6. Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum. Régulier, E., Trottier, Y., Perrin, V., Aebischer, P., Déglon, N. Hum. Mol. Genet. (2003) [Pubmed]
  7. Proximity mapping of the Tet repressor-tetracycline-Fe2+ complex by hydrogen peroxide mediated protein cleavage. Ettner, N., Metzger, J.W., Lederer, T., Hulmes, J.D., Kisker, C., Hinrichs, W., Ellestad, G.A., Hillen, W. Biochemistry (1995) [Pubmed]
  8. Minocycline attenuates T cell and microglia activity to impair cytokine production in T cell-microglia interaction. Giuliani, F., Hader, W., Yong, V.W. J. Leukoc. Biol. (2005) [Pubmed]
  9. Effect of low dietary calcium on bone metabolism in the SENCAR mouse. Murray, E.J., Murray, S.S., Grisanti, M., Duarte, M.E., Urist, M.R. J. Orthop. Res. (1997) [Pubmed]
  10. Anosmia after doxycycline use. Bleasel, A.F., McLeod, J.G., Lane-Brown, M. Med. J. Aust. (1990) [Pubmed]
  11. Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Dickins, R.A., Hemann, M.T., Zilfou, J.T., Simpson, D.R., Ibarra, I., Hannon, G.J., Lowe, S.W. Nat. Genet. (2005) [Pubmed]
  12. Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16. Rossi, F.M., Guicherit, O.M., Spicher, A., Kringstein, A.M., Fatyol, K., Blakely, B.T., Blau, H.M. Nat. Genet. (1998) [Pubmed]
  13. Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. Van Meir, E.G., Polverini, P.J., Chazin, V.R., Su Huang, H.J., de Tribolet, N., Cavenee, W.K. Nat. Genet. (1994) [Pubmed]
  14. Rickettsialpox in a New York City hospital, 1980 to 1989. Kass, E.M., Szaniawski, W.K., Levy, H., Leach, J., Srinivasan, K., Rives, C. N. Engl. J. Med. (1994) [Pubmed]
  15. Efficacy of neonatal ocular prophylaxis for the prevention of chlamydial and gonococcal conjunctivitis. Hammerschlag, M.R., Cummings, C., Roblin, P.M., Williams, T.H., Delke, I. N. Engl. J. Med. (1989) [Pubmed]
  16. Prophylaxis of gonococcal and chlamydial ophthalmia neonatorum. A comparison of silver nitrate and tetracycline. Laga, M., Plummer, F.A., Piot, P., Datta, P., Namaara, W., Ndinya-Achola, J.O., Nzanze, H., Maitha, G., Ronald, A.R., Pamba, H.O. N. Engl. J. Med. (1988) [Pubmed]
  17. Cost-effectiveness of combined treatment for endocervical gonorrhea. Considering co-infection with Chlamydia trachomatis. Washington, A.E., Browner, W.S., Korenbrot, C.C. JAMA (1987) [Pubmed]
  18. Single-dose tetracycline therapy for shigellosis in adults. Pickering, L.K., DuPont, H.L., Olarte, J. JAMA (1978) [Pubmed]
  19. An epidemic of resistant Salmonella in a nursery. Animal-to-human spread. Lyons, R.W., Samples, C.L., DeSilva, H.N., Ross, K.A., Julian, E.M., Checko, P.J. JAMA (1980) [Pubmed]
  20. A novel type of transposon generated by insertion element IS102 present in a pSC101 derivative. Machida, Y., Machida, C., Ohtsubo, E. Cell (1982) [Pubmed]
  21. Diminished rates of bone formation in normal black adults. Weinstein, R.S., Bell, N.H. N. Engl. J. Med. (1988) [Pubmed]
  22. Growth hormone stimulates the proliferation of cultured chondrocytes from rabbit ear and rat rib growth cartilage. Madsen, K., Friberg, U., Roos, P., Edén, S., Isaksson, O. Nature (1983) [Pubmed]
  23. Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts. Bohl, D., Naffakh, N., Heard, J.M. Nat. Med. (1997) [Pubmed]
  24. Control of memory formation through regulated expression of a CaMKII transgene. Mayford, M., Bach, M.E., Huang, Y.Y., Wang, L., Hawkins, R.D., Kandel, E.R. Science (1996) [Pubmed]
  25. Sclerosis of thyroid cyst with tetracycline. Ryan, W.G., Schwartz, T.B., Harris, J. N. Engl. J. Med. (1983) [Pubmed]
  26. Interaction of antibiotics with functional sites in 16S ribosomal RNA. Moazed, D., Noller, H.F. Nature (1987) [Pubmed]
  27. c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations. D'Cruz, C.M., Gunther, E.J., Boxer, R.B., Hartman, J.L., Sintasath, L., Moody, S.E., Cox, J.D., Ha, S.I., Belka, G.K., Golant, A., Cardiff, R.D., Chodosh, L.A. Nat. Med. (2001) [Pubmed]
  28. Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation. Li, B., Yu, H., Zheng, W., Voll, R., Na, S., Roberts, A.W., Williams, D.A., Davis, R.J., Ghosh, S., Flavell, R.A. Science (2000) [Pubmed]
  29. Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis. Wu, Z., Xie, Y., Bucher, N.L., Farmer, S.R. Genes Dev. (1995) [Pubmed]
  30. National gonorrhea therapy monitoring study: in vitro antibiotic susceptibility and its correlation with treatment results. Jaffe, H.W., Biddle, J.W., Thornsberry, C., Johnson, R.E., Kaufman, R.E., Reynolds, G.H., Wiesner, P.J. N. Engl. J. Med. (1976) [Pubmed]
  31. Regulation of ribosome phosphorylation and antibiotic sensitivity in Tetrahymena thermophila: A correlation. Hallberg, R.L., Wilson, P.G., Sutton, C. Cell (1981) [Pubmed]
  32. Randomised controlled comparison of single-dose ciprofloxacin and doxycycline for cholera caused by Vibrio cholerae 01 or 0139. Khan, W.A., Bennish, M.L., Seas, C., Khan, E.H., Ronan, A., Dhar, U., Busch, W., Salam, M.A. Lancet (1996) [Pubmed]
  33. Current FDA-approved treatments for Helicobacter pylori and the FDA approval process. Hopkins, R.J. Gastroenterology (1997) [Pubmed]
  34. Treatment of diarrhoea in Indonesian children: what it costs and who pays for it. Lerman, S.J., Shepard, D.S., Cash, R.A. Lancet (1985) [Pubmed]
  35. Inflammatory responses induced by the filarial nematode Brugia malayi are mediated by lipopolysaccharide-like activity from endosymbiotic Wolbachia bacteria. Taylor, M.J., Cross, H.F., Bilo, K. J. Exp. Med. (2000) [Pubmed]
  36. Blocking the transcription factor E2F/DP by dominant-negative mutants in a normal breast epithelial cell line efficiently inhibits apoptosis and induces tumor growth in SCID mice. Bargou, R.C., Wagener, C., Bommert, K., Arnold, W., Daniel, P.T., Mapara, M.Y., Grinstein, E., Royer, H.D., Dörken, B. J. Exp. Med. (1996) [Pubmed]
  37. Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade. Kieser, A., Kilger, E., Gires, O., Ueffing, M., Kolch, W., Hammerschmidt, W. EMBO J. (1997) [Pubmed]
  38. WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis. Englert, C., Hou, X., Maheswaran, S., Bennett, P., Ngwu, C., Re, G.G., Garvin, A.J., Rosner, M.R., Haber, D.A. EMBO J. (1995) [Pubmed]
  39. p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts. Sells, M.A., Boyd, J.T., Chernoff, J. J. Cell Biol. (1999) [Pubmed]
  40. Mycoplasmemia in adult male patients. Simberkoff, M.S., Toharsky, B. JAMA (1976) [Pubmed]
  41. Intrapleural tetracycline for the prevention of recurrent spontaneous pneumothorax. Results of a Department of Veterans Affairs cooperative study. Light, R.W., O'Hara, V.S., Moritz, T.E., McElhinney, A.J., Butz, R., Haakenson, C.M., Read, R.C., Sassoon, C.S., Eastridge, C.E., Berger, R. JAMA (1990) [Pubmed]
  42. Prescribing of tetracycline to children less than 8 years old. A two-year epidemiologic study among ambulatory Tennessee medicaid recipients. Ray, W.A., Federspiel, C.F., Schaffner, W. JAMA (1977) [Pubmed]
  43. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. Weinstein, R.S., Jilka, R.L., Parfitt, A.M., Manolagas, S.C. J. Clin. Invest. (1998) [Pubmed]
WikiGenes - Universities