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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Platelet as a model to test autonomic function in migraine.

In order to evaluate the role of the sympathetic autonomic nervous system (SANS) in common migraine we measured platelet catecholamine levels in a group of patients and in control subjects after 1 and 30 min of supine rest. Common migraine patients showed, at 1 min of supine rest, higher platelet norepinephrine (NE) content in comparison with the controls. This result may reflect a decreased release of platelet dense bodies in migraineurs. The same patients showed after 30' of supine rest a hardly significant increase of platelet NE levels in contrast to the clearly significant increase found in controls. These findings support the hypothesis of sympathetic hypofunction in migraine.[1]

References

  1. Platelet as a model to test autonomic function in migraine. D'Andrea, G., Cananzi, A.R., Morra, M., Fornasiero, S., Zamberlan, F., Ferro-Milone, F., Joseph, R., Grunfeld, S., Welch, K.M. Funct. Neurol. (1989) [Pubmed]
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