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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Assessment of unscheduled DNA synthesis in Fischer 344 rat pachytene spermatocytes exposed to caprolactam or benzoin in vivo.

Male Fischer 344 rats were treated with the non-carcinogenic chemicals CAP and ZOIN. The spermatogenic cells were isolated at selected times post-exposure for assessment of chemically-induced DNA damage by quantitative autoradiography of unscheduled DNA synthesis (UDS). Neither chemical (750 mg/kg administered by gavage) induced UDS in pachytene spermatocytes isolated 12, 24 or 48 h after treatment.[1]


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