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Disease relevance of Spermatocytes


High impact information on Spermatocytes

  • Cyclin A1 is therefore essential for spermatocyte passage into the first meiotic division in male mice, a function that cannot be complemented by the concurrently expressed B-type cyclins [6].
  • In contrast, the apoptotic elimination of spermatocytes with synaptic errors proved to be p53-independent [7].
  • Mlh1-deficient spermatocytes exhibit high levels of prematurely separated chromosomes and arrest in first division meiosis [8].
  • We observed a specific demethylation event in the Pgk-2 gene in prospermatogonia at about the time of birth, about 10 days before the onset of transcription which first occurs in primary spermatocytes [9].
  • High levels of c-myc and c-jun RNAs were also detected in spermatocytes early in the prophase of meiosis [10].

Chemical compound and disease context of Spermatocytes


Biological context of Spermatocytes


Anatomical context of Spermatocytes


Associations of Spermatocytes with chemical compounds


Gene context of Spermatocytes


Analytical, diagnostic and therapeutic context of Spermatocytes


  1. Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1. Nakai, A., Suzuki, M., Tanabe, M. EMBO J. (2000) [Pubmed]
  2. Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis. Bolino, A., Bolis, A., Previtali, S.C., Dina, G., Bussini, S., Dati, G., Amadio, S., Del Carro, U., Mruk, D.D., Feltri, M.L., Cheng, C.Y., Quattrini, A., Wrabetz, L. J. Cell Biol. (2004) [Pubmed]
  3. Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis. van der Weyden, L., Arends, M.J., Chausiaux, O.E., Ellis, P.J., Lange, U.C., Surani, M.A., Affara, N., Murakami, Y., Adams, D.J., Bradley, A. Mol. Cell. Biol. (2006) [Pubmed]
  4. TSP50, a possible protease in human testes, is activated in breast cancer epithelial cells. Shan, J., Yuan, L., Xiao, Q., Chiorazzi, N., Budman, D., Teichberg, S., Xu, H.P. Cancer Res. (2002) [Pubmed]
  5. Sequential analysis of synaptonemal complexes in the repopulating spermatocytes of Rattus norvegicus after restricting the germ cell population to spermatogonia by gossypol treatment. Bhagirath, T., Kundu, S.C. Eur. J. Cell Biol. (1986) [Pubmed]
  6. Cyclin A1 is required for meiosis in the male mouse. Liu, D., Matzuk, M.M., Sung, W.K., Guo, Q., Wang, P., Wolgemuth, D.J. Nat. Genet. (1998) [Pubmed]
  7. The meiotic checkpoint monitoring synapsis eliminates spermatocytes via p53-independent apoptosis. Odorisio, T., Rodriguez, T.A., Evans, E.P., Clarke, A.R., Burgoyne, P.S. Nat. Genet. (1998) [Pubmed]
  8. Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Baker, S.M., Plug, A.W., Prolla, T.A., Bronner, C.E., Harris, A.C., Yao, X., Christie, D.M., Monell, C., Arnheim, N., Bradley, A., Ashley, T., Liskay, R.M. Nat. Genet. (1996) [Pubmed]
  9. Developmental changes in methylation of spermatogenesis-specific genes include reprogramming in the epididymis. Ariel, M., Cedar, H., McCarrey, J. Nat. Genet. (1994) [Pubmed]
  10. Specific expression of nuclear proto-oncogenes before entry into meiotic prophase of spermatogenesis. Wolfes, H., Kogawa, K., Millette, C.F., Cooper, G.M. Science (1989) [Pubmed]
  11. On the mutagenicity of methadone hydrochloride. Induced dominant lethal mutation and spermatocyte chromosomal aberrations in treated males. Badr, F.M., Rabouh, S.A., Badr, R.S. Mutat. Res. (1979) [Pubmed]
  12. Clastogenic effects of cis-diamminedichloroplatinum. II. Induction of chromosomal aberrations in primary spermatocytes and spermatogonial stem cells of mice. Adler, I.D., el Tarras, A. Mutat. Res. (1990) [Pubmed]
  13. Testicular toxicity of 2-methoxyacetaldehyde, a possible metabolite of ethylene glycol monomethyl ether, in the rat. Foster, P.M., Blackburn, D.M., Moore, R.B., Lloyd, S.C. Toxicol. Lett. (1986) [Pubmed]
  14. Effects of long-term zearalenone administration on spermatogenesis and serum luteinizing hormone, follicle-stimulating hormone, and prolactin values in male rats. Milano, G.D., Becú-Villalobos, D., Tapia, M.O. Am. J. Vet. Res. (1995) [Pubmed]
  15. Effects of cisplatin on the mouse testis. Vawda, A.I., Davies, A.G. Acta Endocrinol. (1986) [Pubmed]
  16. Synaptonemal complex complement of man in spreads of spermatocytes, with details of the sex chromosome pair. Moses, M.J., Counce, S.J., Paulson, D.F. Science (1975) [Pubmed]
  17. The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis. Akhmanova, A., Mausset-Bonnefont, A.L., van Cappellen, W., Keijzer, N., Hoogenraad, C.C., Stepanova, T., Drabek, K., van der Wees, J., Mommaas, M., Onderwater, J., van der Meulen, H., Tanenbaum, M.E., Medema, R.H., Hoogerbrugge, J., Vreeburg, J., Uringa, E.J., Grootegoed, J.A., Grosveld, F., Galjart, N. Genes Dev. (2005) [Pubmed]
  18. Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation. de Vries, F.A., de Boer, E., van den Bosch, M., Baarends, W.M., Ooms, M., Yuan, L., Liu, J.G., van Zeeland, A.A., Heyting, C., Pastink, A. Genes Dev. (2005) [Pubmed]
  19. Inactivation of a sperm motility gene by insertion of an epidermal growth factor receptor transgene whose product is overexpressed and compartmentalized during spermatogenesis. Merlino, G.T., Stahle, C., Jhappan, C., Linton, R., Mahon, K.A., Willingham, M.C. Genes Dev. (1991) [Pubmed]
  20. Growth and reproduction complex in the rat. Genes linked to the major histocompatibility complex that affect development. Kunz, H.W., Gill, T.J., Dixon, B.D., Taylor, F.H., Greiner, D.L. J. Exp. Med. (1980) [Pubmed]
  21. The Caenorhabditis elegans spe-26 gene is necessary to form spermatids and encodes a protein similar to the actin-associated proteins kelch and scruin. Varkey, J.P., Muhlrad, P.J., Minniti, A.N., Do, B., Ward, S. Genes Dev. (1995) [Pubmed]
  22. Cellular distribution of insulin-degrading enzyme gene expression. Comparison with insulin and insulin-like growth factor receptors. Bondy, C.A., Zhou, J., Chin, E., Reinhardt, R.R., Ding, L., Roth, R.A. J. Clin. Invest. (1994) [Pubmed]
  23. The Drosophila kinesin-like protein KLP3A is a midbody component required for central spindle assembly and initiation of cytokinesis. Williams, B.C., Riedy, M.F., Williams, E.V., Gatti, M., Goldberg, M.L. J. Cell Biol. (1995) [Pubmed]
  24. Mutations in twinstar, a Drosophila gene encoding a cofilin/ADF homologue, result in defects in centrosome migration and cytokinesis. Gunsalus, K.C., Bonaccorsi, S., Williams, E., Verni, F., Gatti, M., Goldberg, M.L. J. Cell Biol. (1995) [Pubmed]
  25. Androgen-dependent apoptosis in male germ cells is regulated through the proto-oncoprotein Cbl. El Chami, N., Ikhlef, F., Kaszas, K., Yakoub, S., Tabone, E., Siddeek, B., Cunha, S., Beaudoin, C., Morel, L., Benahmed, M., Régnier, D.C. J. Cell Biol. (2005) [Pubmed]
  26. Positional cloning and characterization of Mei1, a vertebrate-specific gene required for normal meiotic chromosome synapsis in mice. Libby, B.J., Reinholdt, L.G., Schimenti, J.C. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  27. Immunohistochemical localization of 3': 5'-cyclic AMP and 3': 5'-cyclic GMP in rat liver, intestine, and testis. Ong, S.H., Whitley, T.H., Stowe, N.W., Steiner, A.L. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  28. Novel role for a sterol response element binding protein in directing spermatogenic cell-specific gene expression. Wang, H., San Agustin, J.T., Witman, G.B., Kilpatrick, D.L. Mol. Cell. Biol. (2004) [Pubmed]
  29. Testicular xenografts: a novel approach to study cytotoxic damage in juvenile primate testis. Jahnukainen, K., Ehmcke, J., Schlatt, S. Cancer Res. (2006) [Pubmed]
  30. Failure of spermatogenesis in mouse lines deficient in the Na(+)-K(+)-2Cl(-) cotransporter. Pace, A.J., Lee, E., Athirakul, K., Coffman, T.M., O'Brien, D.A., Koller, B.H. J. Clin. Invest. (2000) [Pubmed]
  31. Distribution of the Rad51 recombinase in human and mouse spermatocytes. Barlow, A.L., Benson, F.E., West, S.C., Hultén, M.A. EMBO J. (1997) [Pubmed]
  32. Spnr, a murine RNA-binding protein that is localized to cytoplasmic microtubules. Schumacher, J.M., Lee, K., Edelhoff, S., Braun, R.E. J. Cell Biol. (1995) [Pubmed]
  33. Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly. Jurczyk, A., Gromley, A., Redick, S., San Agustin, J., Witman, G., Pazour, G.J., Peters, D.J., Doxsey, S. J. Cell Biol. (2004) [Pubmed]
  34. The DNA mismatch-repair MLH3 protein interacts with MSH4 in meiotic cells, supporting a role for this MutL homolog in mammalian meiotic recombination. Santucci-Darmanin, S., Neyton, S., Lespinasse, F., Saunières, A., Gaudray, P., Paquis-Flucklinger, V. Hum. Mol. Genet. (2002) [Pubmed]
  35. Atm inactivation results in aberrant telomere clustering during meiotic prophase. Pandita, T.K., Westphal, C.H., Anger, M., Sawant, S.G., Geard, C.R., Pandita, R.K., Scherthan, H. Mol. Cell. Biol. (1999) [Pubmed]
  36. Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I. Barlow, C., Liyanage, M., Moens, P.B., Tarsounas, M., Nagashima, K., Brown, K., Rottinghaus, S., Jackson, S.P., Tagle, D., Ried, T., Wynshaw-Boris, A. Development (1998) [Pubmed]
  37. MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells. Touré, A., Dorseuil, O., Morin, L., Timmons, P., Jégou, B., Reibel, L., Gacon, G. J. Biol. Chem. (1998) [Pubmed]
  38. The nuclear RNA-binding protein Sam68 translocates to the cytoplasm and associates with the polysomes in mouse spermatocytes. Paronetto, M.P., Zalfa, F., Botti, F., Geremia, R., Bagni, C., Sette, C. Mol. Biol. Cell (2006) [Pubmed]
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