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Wentland, M.P. et al.

Synthesis and bacterial DNA gyrase inhibitory properties of a spirocyclopropylquinolone derivative.

A novel conformationally restricted 1-cyclopropylquinolone (1) that incorporates structural features of both ofloxacin and ciprofloxacin has been prepared. Compound 1 was found to be a DNA gyrase inhibitor having potency similar to ofloxacin but less than ciprofloxacin. The cellular inhibitory and in vivo antibacterial potencies of 1 were found to be less than those of the two reference agents.[1]

References

Synthesis and bacterial DNA gyrase inhibitory properties of a spirocyclopropylquinolone derivative. Wentland, M.P., Perni, R.B., Dorff, P.H., Rake, J.B. J. Med. Chem. (1988) [Pubmed]

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